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作为针对细菌和真菌病原体的糖缀合物疫苗的载体蛋白的交叉反应物质（CRM197）。

Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens.

机构信息

Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia.

Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia.

出版信息

Int J Biol Macromol. 2022 Oct 1;218:775-798. doi: 10.1016/j.ijbiomac.2022.07.137. Epub 2022 Jul 22.

DOI:10.1016/j.ijbiomac.2022.07.137
PMID:35872318
Abstract

This paper gives an overview of conjugate glycovaccines which contain recombinant diphtheria toxoid CRM197 as a carrier protein. A special focus is given to synthetic methods used for preparation of neoglycoconjugates of CRM197 with oligosaccharide epitopes of cell surface carbohydrates of pathogenic bacteria and fungi. Syntheses of commercial vaccines and laboratory specimen on the basis of CRM197 are outlined briefly.

摘要

本文概述了包含重组白喉毒素 CRM197 作为载体蛋白的结合糖疫苗。特别关注了用于制备 CRM197 与致病菌和真菌表面碳水化合物寡糖表位的新型糖缀合物的合成方法。简要概述了基于 CRM197 的商业疫苗和实验室标本的合成。

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