Kamneva Anastasia A, Yashunsky Dmitry V, Khatuntseva Elena A, Nifantiev Nikolay E
N. D. Zelinsky Institute of Organic Chemistry, Leninsky pr. 47, Moscow 119991, Russia.
Molecules. 2023 Jul 27;28(15):5688. doi: 10.3390/molecules28155688.
Synthesis of spacer-armed pseudodi-, pseudotetra-, and pseudohexasaccharides related to the capsular phosphoglycan of type , the second most virulent serotype of (after type ), was performed for the first time via iterative chain elongation using H-phosphonate chemistry for the formation of inter-unit phosphodiester bridges. These compounds were prepared for the design of neoglycoconjugates, as exemplified by the transformation of the obtained pseudohexasaccharide derivative into a biotinylated glycoconjugate suitable for use in immunological studies, particularly in diagnostic screening systems as a coating antigen for streptavidin-coated plates and chip slides.
首次通过使用H-膦酸酯化学进行迭代链延长来合成与[细菌名称]第二毒力血清型（仅次于[细菌名称]的[血清型名称]）的荚膜磷酸聚糖相关的间隔臂化假二糖、假四糖和假六糖，以形成单元间磷酸二酯桥。制备这些化合物用于新糖缀合物的设计，例如将所得假六糖衍生物转化为适用于免疫研究的生物素化糖缀合物，特别是在诊断筛选系统中作为链霉亲和素包被板和芯片载玻片的包被抗原。
