利用核黄素作为光敏剂对埃及伊蚊幼虫进行光灭活。

Photoinactivation of Aedes aegypti larvae using riboflavin as photosensitizer.

机构信息

Grupo de Óptica e Fotônica, Instituto de Física, Universidade Federal de Mato Grosso do Sul, CP 549, Campo Grande, MS 79070-900, Brazil; São Carlos Institute of Physics, University of São Paulo, São Carlos 13566-590, Brazil.

Grupo de Óptica e Fotônica, Instituto de Física, Universidade Federal de Mato Grosso do Sul, CP 549, Campo Grande, MS 79070-900, Brazil.

出版信息

Photodiagnosis Photodyn Ther. 2022 Sep;39:103030. doi: 10.1016/j.pdpdt.2022.103030. Epub 2022 Jul 21.

DOI:10.1016/j.pdpdt.2022.103030

PMID:35872352

Abstract

More than half of the global population lives in areas where the Aedes aegypti mosquito is present. Efforts have been made to deal with the population of this mosquito in the larval and adult stages to prevent outbreaks of diseases (Dengue, Zika, Chikungunya, and Yellow Fever). In this scenario, photodynamic inactivation may be an effective alternative method to control this vector population. To evaluate the efficacy of the riboflavin - B2 vitamin - as photosensitizer (PS) in the photodynamic inactivation of Ae. aegypti larvae, different concentrations (0; 0.005; 0.010; 0.025; 0.050; 0.075 and 0.100 mg mL) were evaluated under white light from RGB LEDs at a light dose of 495.2 J cm. The results reveal that riboflavin can be successfully applied as a PS agent to photoinactivate Ae. aegypti larvae, showing its potential to deal with the larvae population.

摘要

超过一半的全球人口生活在埃及伊蚊存在的地区。人们一直在努力处理幼虫和成虫阶段的这种蚊子的数量，以防止登革热、寨卡病毒、基孔肯雅热和黄热病等疾病的爆发。在这种情况下，光动力失活可能是一种控制这种媒介种群的有效替代方法。为了评估核黄素-B2 维生素作为光敏剂 (PS) 在埃及伊蚊幼虫光动力失活中的功效，在白光下（来自 RGB LED），在光照剂量为 495.2 J cm 时，评估了不同浓度（0；0.005；0.010；0.025；0.050；0.075 和 0.100 mg mL）的效果。结果表明，核黄素可以成功地用作 PS 试剂来光灭活埃及伊蚊幼虫，显示出其处理幼虫种群的潜力。