Department of Clinical Nutrition, Affiliated Hospital of Shandong University of TCM, Jinan 250011, China.
Comput Math Methods Med. 2022 Jul 14;2022:5900024. doi: 10.1155/2022/5900024. eCollection 2022.
Chinese herbal formulas have certain effects on patients with breast cancer (BC). This article discussed the effect of Buqi Yangxue decoction on the immune function and nutritional status of BC patients and provided an evidence for traditional Chinese medicine (TCM) to improve the quality of life and curative effect of BC patients.
66 cases of BC patients were divided into control group ( =33) and Chinese herbal formula group ( =33). The control group was received with TE chemotherapy, and the Chinese herbal formula group was received with Buqi Yangxue decoction combined with TE chemotherapy. Nutritional status, immune function, TCM symptom quantitative score, and adverse reactions were compared between the two groups.
There was no difference in all indexes between the two groups before intervention. After 4 weeks, the nutritional indexes ALB, PA, TRF, and TP in Chinese herbal formula group were higher than those in control group, except HGb. CD3+, CD4+, and CD4+/CD8+ in both groups were sharply higher than before treatment, while CD8+ was dramatically lower, and the changes in Chinese herbal formula group were more obvious than those in control group. In Chinese herbal formula group, the levels of IgG, IgA, and IgM were sharply increased compared with control group. The TCM syndrome scores in both groups were decreased significantly after treatment, especially in Chinese herbal formula group. In addition, nausea and vomiting, inappetence, liver function impairment, leukopenia, and thrombocytopenia occurred in both groups. There was no clear difference in the incidence of adverse reactions between Chinese herbal formula group and control group.
Buqi Yangxue decoction can effectively improve the nutritional status and immune function of BC patients, which has important clinical significance for the later comprehensive treatment.
中草药方剂对乳腺癌（BC）患者具有一定疗效。本文探讨了补气养血汤对 BC 患者免疫功能和营养状况的影响，为中医药改善 BC 患者生活质量和疗效提供了依据。
将 66 例 BC 患者分为对照组（n=33）和中药组（n=33）。对照组接受 TE 化疗，中药组接受补气养血汤联合 TE 化疗。比较两组患者的营养状况、免疫功能、中医症状量化评分和不良反应。
两组患者干预前各项指标均无差异。干预 4 周后，中药组的营养指标 ALB、PA、TRF、TP 高于对照组，除 HGb 外。两组 CD3+、CD4+和 CD4+/CD8+均明显高于治疗前，而 CD8+明显降低，中药组变化较对照组更为明显。与对照组相比，中药组 IgG、IgA 和 IgM 水平明显升高。两组治疗后中医证候评分均明显下降，尤其是中药组。此外，两组均出现恶心呕吐、食欲不振、肝功能损害、白细胞减少和血小板减少。中药组与对照组不良反应发生率无明显差异。
补气养血汤能有效改善 BC 患者的营养状况和免疫功能，对后期综合治疗具有重要的临床意义。
