State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, PR China.
Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, 519041, PR China.
Carbohydr Polym. 2021 Jun 1;261:117863. doi: 10.1016/j.carbpol.2021.117863. Epub 2021 Feb 25.
Codonopsis pilosula (Franch.) Nannf., as a well-known homology plant of medicine and food, has the function of replenishing the Qi, strengthening the spleen and tonifying the lung, nourishing the blood and engendering the liquid in traditional Chinese medicine. Accumulating evidence has demonstrated that the C. pilosula polysaccharides (CPPs) are one of the major and representative pharmacologically active macromolecules and present multiple biological activities both in vitro and in vivo methods, such as immunomodulatory, antitumor, antioxidant, neuroprotective, antiviral, anti-inflammatory, anti-fatigue, hypoglycemic, anti-hypoxia, renoprotective, gastroprotective, hepatoprotective, and prebiotic. The purpose of the present review is to provide comprehensively and systematically reorganized information in the extraction and purification, structure characterization, biological activities and the underlying mechanisms of action as well as toxicities of CPPs to support their therapeutic potentials and sanitarian functions. New valuable insights for the future researches regarding CPPs were also proposed in the fields of therapeutic agents and functional foods.
党参（Franch.）Nannf.，作为一种著名的药食同源植物，具有补气、健脾益肺、养血生津的功效。越来越多的证据表明，党参多糖（CPPs）是主要的和有代表性的药理活性大分子之一，具有多种生物活性，包括体外和体内方法，如免疫调节、抗肿瘤、抗氧化、神经保护、抗病毒、抗炎、抗疲劳、降血糖、抗缺氧、肾保护、胃保护、肝保护和益生元。本综述的目的是提供全面系统地重组的信息，包括 CPPs 的提取和纯化、结构特征、生物活性和作用机制以及毒性，以支持它们的治疗潜力和卫生功能。还针对 CPPs 在治疗剂和功能性食品领域的未来研究提出了新的有价值的见解。
