Shah Nishi, Asdourian Maria S, Jacoby Ted V, Chen Steven T
Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114 USA.
Virginia Commonwealth University School of Medicine, Richmond, VA USA.
Curr Dermatol Rep. 2022;11(3):146-157. doi: 10.1007/s13671-022-00364-7. Epub 2022 Jul 16.
Neutrophilic dermatoses are a heterogeneous group of disorders with significant overlap in associated conditions, clinical presentation, and histopathologic features. This review provides a structural overview of neutrophilic dermatoses that may present in the inpatient setting along with diagnostic work-up and management strategies.
Sweet's syndrome has been found in patients with coronavirus disease 2019 (COVID-19). Pyoderma gangrenosum (PG) has been shown to be equally associated with ulcerative colitis and Crohn's disease. A clinical trial shows that cyclosporine is equally effective as prednisone in treating PG. Neutrophilic eccrine hidradenitis has been found in the setting of newer antineoplastic medications, such as BRAF inhibitors, as well as in the setting of malignancy without chemotherapy exposure.
Neutrophilic dermatoses are a rare and complex group of dermatoses with varying and overlapping clinical presentations. Physicians should be aware of the growing list of associated diseases in order to build a better differential diagnosis or to potentially investigate for co-existing disease.
嗜中性皮病是一组异质性疾病，在相关病症、临床表现和组织病理学特征方面有显著重叠。本综述提供了可能出现在住院环境中的嗜中性皮病的结构概述，以及诊断检查和管理策略。
在2019冠状病毒病（COVID-19）患者中发现了Sweet综合征。坏疽性脓皮病（PG）已被证明与溃疡性结肠炎和克罗恩病同样相关。一项临床试验表明，环孢素在治疗PG方面与泼尼松同样有效。嗜中性小汗腺炎已在使用新型抗肿瘤药物（如BRAF抑制剂）的情况下被发现，以及在未接触化疗的恶性肿瘤情况下被发现。
嗜中性皮病是一组罕见且复杂的皮肤病，临床表现各异且有重叠。医生应了解越来越多的相关疾病，以便更好地进行鉴别诊断或潜在地调查是否存在并存疾病。
