超声辅助合成异吲哚啉-1-酮衍生物

Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives.

作者信息

Mardjan Muhammad Idham Darussalam, Hariadi Muhamad Fadhly, Putri Indah Mutiara, Musyarrofah Nilna Amalia, Salimah Muflihah, Purwono Bambang, Commeiras Laurent

机构信息

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Bulaksumur POS BLS 21 Yogyakarta 55281 Indonesia

Aix Marseille Univ., CNRS, Centrale Marseille, iSm2 Marseille 13013 France.

出版信息

RSC Adv. 2022 Jun 29;12(29):19016-19021. doi: 10.1039/d2ra02720h. eCollection 2022 Jun 22.

A small library of 3-hydroxyisoindolin-1-ones has been prepared from 3-alkylidenephtalides under ultrasonic irradiation. This practical synthesis is featured by group tolerance, high efficiency and yields. The reaction can also be performed in multigram scale and be further extended to access other motifs of isoindolin-1-ones in a one-pot fashion.