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超声辅助合成异吲哚啉-1-酮衍生物

Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives.

作者信息

Mardjan Muhammad Idham Darussalam, Hariadi Muhamad Fadhly, Putri Indah Mutiara, Musyarrofah Nilna Amalia, Salimah Muflihah, Purwono Bambang, Commeiras Laurent

机构信息

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Bulaksumur POS BLS 21 Yogyakarta 55281 Indonesia

Aix Marseille Univ., CNRS, Centrale Marseille, iSm2 Marseille 13013 France.

出版信息

RSC Adv. 2022 Jun 29;12(29):19016-19021. doi: 10.1039/d2ra02720h. eCollection 2022 Jun 22.

DOI:10.1039/d2ra02720h
PMID:35873335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9241359/
Abstract

A small library of 3-hydroxyisoindolin-1-ones has been prepared from 3-alkylidenephtalides under ultrasonic irradiation. This practical synthesis is featured by group tolerance, high efficiency and yields. The reaction can also be performed in multigram scale and be further extended to access other motifs of isoindolin-1-ones in a one-pot fashion.

摘要

在超声辐射下，由3-亚烷基苯酞制备了一个小型的3-羟基异吲哚啉-1-酮文库。这种实用的合成方法具有基团耐受性、高效性和高收率的特点。该反应还可以在数克规模上进行，并进一步扩展以一锅法获得异吲哚啉-1-酮的其他结构单元。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/76fcdbf18a5b/d2ra02720h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/41e84f1cb7ad/d2ra02720h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/d1b64eb5d865/d2ra02720h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/9ede422a447b/d2ra02720h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/f0584f435ed2/d2ra02720h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/76fcdbf18a5b/d2ra02720h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/41e84f1cb7ad/d2ra02720h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/d1b64eb5d865/d2ra02720h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/9ede422a447b/d2ra02720h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/f0584f435ed2/d2ra02720h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd46/9241359/76fcdbf18a5b/d2ra02720h-s4.jpg

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