一种用于构建受生物碱启发的吲哚/内酰胺多环化合物的可调铜催化多组分反应。
A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles.
作者信息
Mardjan M I D, Perie S, Parrain J-L, Commeiras L
机构信息
Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.
出版信息
Org Biomol Chem. 2017 Apr 11;15(15):3304-3309. doi: 10.1039/c7ob00532f.
PMID:28358155
Abstract
A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.
摘要
报道了一种通用的铜（I）催化的级联多组分反应策略，该策略涉及容易获得的（Z）-3-碘丙烯酸、末端炔烃和伯胺，可生成基于生物相关吲哚/内酰胺支架的多种复杂杂环骨架。
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