L. cv. DANGJO改善了由高脂饮食和链脲佐菌素诱导的2型糖尿病动物模型中的高血糖状况。
L. cv. DANGJO ameliorated hyperglycemia in type 2 diabetes animal model induced by high-fat diet and streptozotocin.
作者信息
Kim Jin Tae, Zhou Yimeng, Qiu Shuai, Lee Seung Beom, Park Ho Jin, Kim Min Jeong, Jung Sung Keun, Seo Eunbin, Kim Young-Jun, Lee Hong Jin
机构信息
Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 South Korea.
School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566 South Korea.
出版信息
Food Sci Biotechnol. 2022 Mar 25;31(8):1073-1080. doi: 10.1007/s10068-022-01068-1. eCollection 2022 Jul.
In this study, it was evaluated the effect of freeze-dried powder of L. cv. DANGJO (DJ) on ameliorating hyperglycemia in type 2 diabetes rat model induced by high-fat diet (HFD) and streptozotocin (STZ). Oral administration of DJ significantly reduced non-fasting blood glucose (NFBG) and insulin levels, as well as glycated hemoglobin (HbA1c) level, a representative marker for diabetes, in HFD/STZ treated rats whereas the administration of green hot pepper (GHP) and green sweet pepper (GSP) did not show the significant effect. Quercitrin was quantified (40.97 mg/100 g of DJ) by HPLC, and administration of the same amount of quercitrin with DJ exerted the significant reduction of blood glucose level, strongly supporting that quercitrin is the key component in ameliorating the hyperglycemia of DJ in HFD/STZ treated rats. These results suggest that DJ can be considered as a potent functional food in preventing hyperglycemia in type 2 diabetes mellitus.
在本研究中，评估了L. cv. DANGJO（DJ）冻干粉对改善高脂饮食（HFD）和链脲佐菌素（STZ）诱导的2型糖尿病大鼠模型高血糖的作用。口服DJ可显著降低HFD/STZ处理大鼠的非空腹血糖（NFBG）、胰岛素水平以及糖化血红蛋白（HbA1c）水平（糖尿病的代表性标志物），而给予青椒（GHP）和甜椒（GSP）则未显示出显著效果。通过高效液相色谱法对槲皮苷进行定量（40.97 mg/100 g DJ），给予与DJ等量的槲皮苷可显著降低血糖水平，有力地支持了槲皮苷是改善HFD/STZ处理大鼠DJ高血糖的关键成分。这些结果表明，DJ可被视为预防2型糖尿病高血糖的有效功能食品。
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