黑树莓提取物可通过调节食用氧化三甲胺高脂饮食大鼠的肠道微生物组成和血清胆汁酸谱来降低血清低密度脂蛋白胆固醇。
Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet.
作者信息
Lim Taehwan, Lee Kiuk, Kim Ryun Hee, Cha Kwang Hyun, Koo Song Yi, Moon Eun Chae, Hwang Keum Taek
机构信息
Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul, 08826 South Korea.
BK21 FOUR Education and Research Team for Sustainable Food & Nutrition, Seoul National University, Seoul, 08826 South Korea.
出版信息
Food Sci Biotechnol. 2022 Apr 10;31(8):1041-1051. doi: 10.1007/s10068-022-01079-y. eCollection 2022 Jul.
UNLABELLED
Blood trimethylamine-N-oxide (TMAO) has been associated with cardiovascular disease. Black raspberry (, BR) has been regarded to be beneficial for cardiovascular health. This study aimed to investigate how BR extract affects serum lipid profile, gut microbial composition, metabolites in rats fed TMAO with a high-fat diet. Dietary TMAO increased serum LDL cholesterol, while BR extract decreased its level. α-Diversity of gut microbiota was not changed; however, in the rats fed TMAO, and were enriched, while was reduced. The BR supplementation could restore , , and . The BR supplementation increased cecal hippuric acid and serum farnesoid X receptor-antagonistic bile acids, including ursodeoxycholic acid (UDCA), tauro-α-muricholic acid, and tauro-UDCA. The BR supplementation tended to upregulate and expressions while downregulating and expressions. BR extract affects the gut bacterial community and microbial metabolites, lowering serum LDL cholesterol in rats with elevated serum TMAO.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-022-01079-y.
未标注
血液中的氧化三甲胺（TMAO）与心血管疾病有关。黑树莓（BR）被认为对心血管健康有益。本研究旨在探讨BR提取物如何影响喂食含TMAO高脂饮食大鼠的血脂谱、肠道微生物组成和代谢产物。膳食TMAO会增加血清低密度脂蛋白胆固醇，而BR提取物可降低其水平。肠道微生物群的α多样性未改变；然而，在喂食TMAO的大鼠中，[具体微生物名称1]和[具体微生物名称2]增多，而[具体微生物名称3]减少。补充BR可恢复[具体微生物名称1]、[具体微生物名称2]和[具体微生物名称3]。补充BR可增加盲肠马尿酸和血清法尼醇X受体拮抗型胆汁酸，包括熊去氧胆酸（UDCA）、牛磺-α-鼠胆酸和牛磺-UDCA。补充BR倾向于上调[具体基因1]和[具体基因2]的表达，同时下调[具体基因3]和[具体基因4]的表达。BR提取物影响肠道细菌群落和微生物代谢产物，降低血清TMAO升高大鼠的血清低密度脂蛋白胆固醇。
补充信息
在线版本包含可在10.1007/s10068-022-01079-y获取的补充材料。
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