肠道微生物代谢产物与血压调节：聚焦于短链脂肪酸和氧化三甲胺
Gut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO.
作者信息
Poll Brian G, Cheema Muhammad Umar, Pluznick Jennifer L
机构信息
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
Physiology (Bethesda). 2020 Jul 1;35(4):275-284. doi: 10.1152/physiol.00004.2020.
Abstract
Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N oxide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.
摘要
肠道微生物群的变化在血压调节中起关键作用，肠道微生物代谢产物产生的变化可能是一个关键机制。已知的肠道微生物代谢产物包括可通过G蛋白偶联受体发出信号的短链脂肪酸和氧化三甲胺。在本综述中，我们概述了迄今为止记录在案的在血压调节中起作用的肠道微生物代谢产物。
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