Lim Taehwan, Lee Kiuk, Kim Ryun Hee, Ryu Juhee, Cha Kwang Hyun, Park Sun Young, Koo Song Yi, Hwang Keum Taek
Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul, 08826 Korea.
BK21 FOUR Education and Research Team for Sustainable Food & Nutrition, Seoul National University, Seoul, 08826 Korea.
Food Sci Biotechnol. 2023 Feb 13;32(4):577-587. doi: 10.1007/s10068-023-01267-4. eCollection 2023 Mar.
In our previous study, black raspberry (BR) reduced the serum levels of trimethylamine--oxide and cholesterol in rats fed excessive choline with a high-fat diet (HFC). We hypothesized that gut microbiota could play a crucial role in the production of trimethylamine and microbial metabolites, and BR could influence gut microbial composition. This study aimed to elucidate the role of BR on changes in gut microbiota and microbial metabolites in the rats. The phylogenetic diversity of gut microbiota was reduced in the rats fed HFC, while that in the BR-fed group was restored. The BR supplementation enriched and reduced cluster XIVa. In the BR-fed group, most cecal bile acids and hippuric acid increased, while serum lithocholic acid was reduced. The BR supplementation upregulated and downregulated . These results suggest that BR extract may change gut bacterial community, modulate bile acids, and regulate gene expression toward reducing cholesterol.
The online version contains supplementary material available at 10.1007/s10068-023-01267-4.
在我们之前的研究中，黑树莓（BR）降低了高脂胆碱过量饮食（HFC）喂养的大鼠血清中氧化三甲胺和胆固醇的水平。我们推测肠道微生物群可能在三甲胺和微生物代谢产物的产生中起关键作用，并且BR可能会影响肠道微生物组成。本研究旨在阐明BR对大鼠肠道微生物群和微生物代谢产物变化的作用。HFC喂养的大鼠肠道微生物群的系统发育多样性降低，而BR喂养组的则得以恢复。补充BR使XIVa簇增加而减少。在BR喂养组中，大多数盲肠胆汁酸和马尿酸增加，而血清石胆酸减少。补充BR上调和下调。这些结果表明，BR提取物可能会改变肠道细菌群落、调节胆汁酸并调节基因表达以降低胆固醇。
在线版本包含可在10.1007/s10068-023-01267-4获取的补充材料。
