Wang Yinghong, Hu Xiaojie, Sun Yancai, Huang Yan
Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
Front Pharmacol. 2022 Jul 8;13:942209. doi: 10.3389/fphar.2022.942209. eCollection 2022.
It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H-activated cation channel family. Recently, many studies have been conducted on ASIC1a and inflammatory immune diseases. Here, in this review, we will focus on the role of ASIC1a in several inflammatory immune diseases so as to provide new perspectives for clinical treatment.
人们公认，慢性炎症与细胞外质子浓度升高有关。酸敏感离子通道1a（ASIC1a）属于细胞外H⁺激活的阳离子通道家族。近年来，针对ASIC1a与炎症性免疫疾病开展了许多研究。在此综述中，我们将聚焦于ASIC1a在几种炎症性免疫疾病中的作用，以便为临床治疗提供新的视角。
