ASIC1a 在癫痫中的作用：一个潜在的治疗靶点。
The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target.
机构信息
Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
出版信息
Curr Neuropharmacol. 2021;19(11):1855-1864. doi: 10.2174/1570159X19666210402102232.
BACKGROUND
Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies. ASIC1a, mainly expressed in the mammalian brain, is a type of protein-gated cation channel. It has been shown to play an important role in the pathological mechanism of various diseases, including stroke, epilepsy, and multiple sclerosis.
METHODS
Data were collected from Web of Science, Medline, PubMed, through searching for these keywords: "Acid-sensing ion channels 1a" or "ASIC1a" and "epilepsy" or "seizure".
RESULTS
The role of ASIC1a in epilepsy remains controversial; it may represent a promising therapeutic target of epilepsy.
CONCLUSION
This review is intended to provide an overview of the structure, trafficking, and molecular mechanisms of ASIC1a in order to elucidate the role of ASIC1a in epilepsy further.
背景
癫痫是人类最常见的脑部疾病之一。致痫灶组织酸中毒是一种常见现象。此外，其在癫痫发生中的作用尚不清楚。酸敏离子通道-1a（ASIC1a）是评估新疗法的潜在途径。ASIC1a 主要在哺乳动物大脑中表达，是一种蛋白门控阳离子通道。已经表明它在各种疾病的病理机制中发挥重要作用，包括中风、癫痫和多发性硬化症。
方法
从 Web of Science、Medline、PubMed 中收集数据，通过搜索以下关键词：“酸敏离子通道 1a”或“ASIC1a”和“癫痫”或“发作”。
结果
ASIC1a 在癫痫中的作用仍存在争议；它可能代表癫痫有希望的治疗靶点。
结论
本综述旨在概述 ASIC1a 的结构、运输和分子机制，以进一步阐明 ASIC1a 在癫痫中的作用。
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