Ali Muhammad, Bracko Oliver
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Biology, University of Miami, Coral Gables, FL, USA.
Neurosci Insights. 2022 Jul 4;17:26331055221109254. doi: 10.1177/26331055221109254. eCollection 2022.
Vascular dysfunction plays a critical role in the development of Alzheimer's disease. Cerebral blood flow reductions of 10% to 25% present early in disease pathogenesis. Vascular Endothelial Growth Factor-A (VEGF-A) drives angiogenesis, which typically addresses blood flow reductions and global hypoxia. However, recent evidence suggests aberrant VEGF-A signaling in Alzheimer's disease may undermine its physiological angiogenic function. Instead of improving cerebral blood flow, VEGF-A contributes to brain capillary stalls and blood flow reductions, likely accelerating cognitive decline. In this commentary, we explore the evidence for pathological VEGF signaling in Alzheimer's disease, and discuss its implications for disease therapy.
血管功能障碍在阿尔茨海默病的发展中起着关键作用。在疾病发病早期，脑血流量会减少10%至25%。血管内皮生长因子A（VEGF-A）驱动血管生成，这通常可解决血流量减少和全身性缺氧问题。然而，最近的证据表明，阿尔茨海默病中VEGF-A信号异常可能会破坏其生理血管生成功能。VEGF-A非但没有改善脑血流量，反而导致脑毛细血管停滞和血流量减少，可能加速认知衰退。在这篇评论中，我们探讨了阿尔茨海默病中病理性VEGF信号传导的证据，并讨论了其对疾病治疗的影响。
