Shrivastav Ashish Kumar, Garg Manish, Aiyer Hema Malini, Sharma Gaurav, Prachi Prachi
Department of Neurosurgery and Neurointervention, Dharamshila Narayana Superspeciality Hospital and Research Centre, New Delhi, India.
Department of Anatomic Pathology, Dharamshila Narayana Superspeciality Hospital and Research Centre, New Delhi, India.
Asian J Neurosurg. 2022 Jun 21;17(1):100-104. doi: 10.1055/s-0042-1748794. eCollection 2022 Mar.
A 50-year-old female presented with a history of seizures, headache, nausea, and vomiting. On imaging, parafalcine meningioma with mass effect features was rendered. She underwent right frontal tumor excision and craniotomy. Pathological examination showed a tumor composed of syncytial aggregates of round to plump fusiform cells forming whorls around prominent branching congested vessels. The tumorous cells expressed α-smooth actin and heavy-chain caldesmon and were negative for epithelial membrane antigen, protein S100, HMB45, CD34, calponin, and desmin, thus providing the final diagnosis of intracranial myopericytoma. The rarity of this benign tumor at an extremely rare location prompted this study. As preoperative radiological investigations are nonspecific in such cases, a detailed and comprehensive pathological examination is mandatory to come to a definitive diagnosis.
一名50岁女性，有癫痫发作、头痛、恶心和呕吐病史。影像学检查显示为具有占位效应特征的大脑镰旁脑膜瘤。她接受了右额叶肿瘤切除术和开颅手术。病理检查显示肿瘤由圆形至饱满梭形细胞的合体聚集物组成，围绕突出的分支充血血管形成漩涡状。肿瘤细胞表达α-平滑肌肌动蛋白和重链钙调蛋白，而上皮膜抗原、蛋白S100、HMB45、CD34、钙调蛋白和结蛋白均为阴性，最终诊断为颅内肌周细胞瘤。这种良性肿瘤在极其罕见的位置出现的罕见性促使了本研究。由于术前放射学检查在此类病例中不具有特异性，因此必须进行详细而全面的病理检查才能做出明确诊断。
