Esmaeilzadeh Mahdiyeh, Divband Baharak, Ranjkesh Bahram, Pournaghi Azar Fatemeh, Yeganeh Sefidan Fatemeh, Kachoei Mojgan, Karimzadeh Behnaz
Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Dentistry and Oral Health, Section for Prosthetic Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Aarhus, Denmark.
Int J Dent. 2022 Jul 14;2022:8155971. doi: 10.1155/2022/8155971. eCollection 2022.
Polymethyl methacrylate (PMMA) is widely used to manufacture removable orthodontic appliances. However, since the porous structure, cold-curing acrylic resins are susceptible to bacterial adhesion and colonization. The aim of this study was to investigate the antibacterial and mechanical properties of a cold-curing PMMA resin containing ZnO and TiO nanoparticles supported on the 4A zeolite. ZnO and TiO nanoparticles supported on the 4A zeolite were synthesized. Nanoparticles were added in three compositions as ZnO/4A, TiO/4A, and ZnO/TiO/4A at 2wt% and 4wt% concentrations to cold-curing acrylic resin powder (SR Triplex® Cold Ivoclar Vivadent AG, FL-9494 Schaan/Liechtenstein). X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), and dynamic light scattering (DLS) were performed to investigate the nanocomposite characteristics. A direct test method was used to assess the antibacterial properties against and . The surface roughness of acrylic samples was measured with a profilometer. Flexural strength was evaluated by a three-point bending test, and one-way ANOVA and Tukey's post hoc tests were used for statistical evaluation of the data. A value of less than 0.05 was considered statistically significant. XRD confirmed the accurate crystalline structure of synthesized nanoparticles; FE-SEM images showed nanoparticle dispersion within polymerized acryl. The addition of 2 and 4 wt% of ZnO/4A, TiO/4A, and ZnO/TiO/4A caused colony reduction in all types of tested microorganisms more than 99% and 100%, respectively. The mean flexural strengths of acrylic specimens containing 2wt% and 4wt% of synthesized nanoparticles were significantly lower than those of the resin without nanoparticles. Fabricated samples showed favorable antibacterial properties but decreased flexural strength.
聚甲基丙烯酸甲酯（PMMA）被广泛用于制造可摘矫治器。然而，由于其多孔结构，冷固化丙烯酸树脂易受细菌黏附和定植。本研究的目的是研究负载在4A沸石上的含ZnO和TiO纳米颗粒的冷固化PMMA树脂的抗菌性能和机械性能。合成了负载在4A沸石上的ZnO和TiO纳米颗粒。将纳米颗粒以三种组合物形式，即ZnO/4A、TiO/4A和ZnO/TiO/4A，分别以2wt%和4wt%的浓度添加到冷固化丙烯酸树脂粉末（SR Triplex® Cold Ivoclar Vivadent AG，FL-9494 Schaan/列支敦士登）中。采用X射线衍射（XRD）、场发射扫描电子显微镜（FE-SEM）、能量色散X射线（EDX）、透射电子显微镜（TEM）和动态光散射（DLS）来研究纳米复合材料的特性。采用直接试验方法评估对[具体细菌名称1]和[具体细菌名称2]的抗菌性能。用轮廓仪测量丙烯酸样品的表面粗糙度。通过三点弯曲试验评估弯曲强度，并使用单向方差分析和Tukey事后检验对数据进行统计评估。P值小于0.05被认为具有统计学意义。XRD证实了合成纳米颗粒的准确晶体结构；FE-SEM图像显示纳米颗粒在聚合丙烯酸内的分散情况。添加2wt%和4wt%的ZnO/4A、TiO/4A和ZnO/TiO/4A分别使所有测试微生物的菌落减少超过99%和100%。含有2wt%和4wt%合成纳米颗粒的丙烯酸试样的平均弯曲强度显著低于不含纳米颗粒的树脂。制备的样品显示出良好的抗菌性能，但弯曲强度降低。
