磷酸二酯酶11A（PDE11A），一种胶质母细胞瘤的潜在生物标志物。
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma.
作者信息
Lee Hyunji, Park Sungjin, Kong Gyeyeong, Kwon So Hee, Park Jisoo, Park Jongsun, Kim Seon-Hwan
机构信息
Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 35015 South Korea.
Department of Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, 35015 South Korea.
出版信息
Toxicol Res. 2022 Apr 12;38(3):409-415. doi: 10.1007/s43188-022-00129-1. eCollection 2022 Jul.
Phosphodiesterase 11A (PDE11A), a 3',5'-cyclic nucleotide phosphodiesterase, is a key regulator of intracellular signaling that functions by degrading cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). However, the function of PDE11A in brain tumors is currently unclear. In this study, we found that PDE11A may be involved in glioblastoma development. The protein and mRNA levels of PDE11A were significantly higher in U87-MG, U251-MG and U343-MG glioblastoma cell lines. Gene expression analyses by deep-sequencing revealed that PDE11A mRNA levels were higher in U87-MG and U251-MG cells compared to other cells in the cerebral cortex. A comprehensive analysis of The Cancer Genome Atlas (TCGA) data revealed that PDE11A expression was also elevated in glioblastoma patients. Taken together, these data indicate that PDE11A expression was increased in glioblastoma cell lines and glioma patients, suggesting that PDE11A could be a putative diagnostic marker and therapeutic target for glioma.
磷酸二酯酶11A（PDE11A）是一种3'，5'-环核苷酸磷酸二酯酶，是细胞内信号传导的关键调节因子，其通过降解环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）发挥作用。然而，PDE11A在脑肿瘤中的功能目前尚不清楚。在本研究中，我们发现PDE11A可能参与胶质母细胞瘤的发展。PDE11A的蛋白质和mRNA水平在U87-MG、U251-MG和U343-MG胶质母细胞瘤细胞系中显著更高。通过深度测序进行的基因表达分析显示，与大脑皮层中的其他细胞相比，U87-MG和U251-MG细胞中的PDE11A mRNA水平更高。对癌症基因组图谱（TCGA）数据的综合分析显示，胶质母细胞瘤患者中PDE11A的表达也升高。综上所述，这些数据表明PDE11A在胶质母细胞瘤细胞系和胶质瘤患者中的表达增加，提示PDE11A可能是胶质瘤的一个潜在诊断标志物和治疗靶点。
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