Bailly Mélina, Boscaro Audrey, Thomas Thierry, Féasson Léonard, Costes Frédéric, Pereira Bruno, Hager Jorg, Estour Bruno, Galusca Bogdan, Metz Lore, Courteix Daniel, Thivel David, Verney Julien, Germain Natacha
Université Clermont Auvergne, CRNH, AME2P, Clermont-Ferrand, France.
Department of Rheumatology, Hôpital Nord, CHU, Saint-Étienne, France.
Front Physiol. 2022 Jul 8;13:921351. doi: 10.3389/fphys.2022.921351. eCollection 2022.
While few studies pointed out low bone mineral densities in constitutionally thin women, little is known about potential explanations. The objective was to further explore bone architecture in both women and men with constitutional thinness to investigate their mechanical muscle-bone coupling (or uncoupling). Thirty constitutionally thin people and 31 normal weight controls participated in the study. Body composition, hip structural analysis, and trabecular bone score were assessed by dual-energy X-ray absorptiometry, bone architecture using high-resolution peripheral quantitative computed tomography, and muscle explorations through histological staining on muscle biopsies. Thirty-two out of the 48 indexes relative to density, geometry, texture, and architecture of bones were found significantly lower ( < 0.05) in constitutionally thin individuals compared with controls. This observation was particularly pronounced in constitutionally thin men. Bone microarchitecture was more altered in weight-supporting bone (tibia) than in non-weight-supporting (radius) bone, which might refer to a normal physiological adaptation (Frost's mechanostat theory). Yet, the heat-maps of correlations analyses showed many alterations of body weight or muscle associations with bone parameters in constitutionally thin individuals contrary to controls. Present results might support the idea of intrinsic disturbances of bone cells independently to the small muscle structure, particularly in men.
虽然很少有研究指出体质消瘦的女性骨矿物质密度较低，但对于其潜在原因却知之甚少。目的是进一步探究体质消瘦的女性和男性的骨骼结构，以研究其肌肉与骨骼的机械耦合（或解耦）情况。30名体质消瘦者和31名正常体重对照者参与了该研究。通过双能X线吸收法评估身体成分、髋部结构分析和小梁骨评分，使用高分辨率外周定量计算机断层扫描评估骨骼结构，并通过对肌肉活检组织进行组织学染色来探索肌肉情况。与对照组相比，在48项与骨骼密度、几何形状、纹理和结构相关的指标中，有32项在体质消瘦者中显著降低（<0.05）。这一观察结果在体质消瘦的男性中尤为明显。承重骨（胫骨）的骨微结构改变比非承重骨（桡骨）更明显，这可能是一种正常的生理适应（弗罗斯特的机械稳态理论）。然而，相关性分析的热图显示，与对照组相反，体质消瘦者的体重或肌肉与骨骼参数之间存在许多改变。目前的结果可能支持骨细胞存在内在紊乱的观点，这种紊乱与小肌肉结构无关, 尤其在男性中。
