Nässberger L, Arbin A, Ostelius J
Nephron. 1987;45(4):286-90. doi: 10.1159/000184165.
The exposure of patients to the plasticizer di-(2-ethylhexyl)phthalate (DEHP) from polyvinyl chloride (PVC) tubes and bags during dialysis has been investigated. In vitro studies of the migration of DEHP from hemodialysis tubes into plasma revealed a migration coefficient of 7.7 micrograms/ml/h. An artificial kidney did not influence the plasma concentration of DEHP. The calculated exposure from a single hemodialysis can be as much as the total annual exposure using continuous ambulatory peritoneal dialysis (CAPD). CAPD fluids in PVC bags contain low concentrations of DEHP and its hydrolysis product mono-(2-ethylhexyl)phthalate (MEHP). These phthalates were analyzed in serum from patients receiving both CAPD and hemodialysis using gas chromatography. A group of patients not yet on dialysis treatment was used as control. In no case could MEHP be detected. The DEHP concentration was 0.8-4.2 micrograms/ml serum in the 17 hemodialysis patients after dialysis and 0.1-0.9 microgram/ml in 4 of the CAPD patients. In 3 of the CAPD and all of the predialysis patients, DEHP could not be detected (less than 0.1 microgram/ml).
已经对患者在透析期间通过聚氯乙烯（PVC）管材和袋子接触增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）的情况进行了调查。关于DEHP从血液透析管迁移至血浆的体外研究显示，迁移系数为7.7微克/毫升/小时。人工肾对DEHP的血浆浓度没有影响。单次血液透析计算得出的暴露量可能高达使用持续性非卧床腹膜透析（CAPD）时的全年总暴露量。PVC袋中的CAPD液含有低浓度的DEHP及其水解产物单（2-乙基己基）邻苯二甲酸酯（MEHP）。使用气相色谱法对接受CAPD和血液透析的患者血清中的这些邻苯二甲酸酯进行了分析。一组尚未接受透析治疗的患者用作对照。在任何情况下均未检测到MEHP。血液透析后的17例血液透析患者血清中DEHP浓度为0.8 - 4.2微克/毫升，4例CAPD患者中为0.1 - 0.9微克/毫升。在3例CAPD患者以及所有透析前患者中，未检测到DEHP（低于0.1微克/毫升）。
