特应性皮炎中的翻译后修饰：当前研究与临床意义
Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance.
作者信息
Ma Xin, Ru Yi, Luo Ying, Kuai Le, Chen Qi-Long, Bai Yun, Liu Ye-Qiang, Chen Jia, Luo Yue, Song Jian-Kun, Zhou Mi, Li Bin
机构信息
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Skin Disease Hospital of Tongji University, Shanghai, China.
出版信息
Front Cell Dev Biol. 2022 Jul 7;10:942838. doi: 10.3389/fcell.2022.942838. eCollection 2022.
Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.
特应性皮炎（AD）是一种慢性复发性皮肤疾病，其特征为免疫系统受损、炎症过度以及皮肤屏障破坏。翻译后修饰（PTMs）是蛋白质翻译后发生的共价和酶促修饰，据报道在炎症和过敏性疾病中发挥作用。然而，PTMs对AD的影响较少受到关注。这篇综述总结了翻译后修饰的六大主要类型（包括磷酸化、乙酰化、泛素化、SUMO化、糖基化、O-糖基化和糖基化终末产物）在AD发病机制中的相关知识，并讨论了疾病管理的机遇。
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