Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Centre for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Int J Biol Sci. 2022 Jul 11;18(12):4756-4767. doi: 10.7150/ijbs.72461. eCollection 2022.
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an ongoing global health pandemic. Since 2019, the pandemic continues to cast a long shadow on all aspects of our lives, bringing huge health and economic burdens to all societies. With our in-depth understanding of COVID-19, from the initial respiratory tract to the later gastrointestinal tract and cardiovascular systems, the multiorgan involvement of this infectious disease has been discovered. Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named nonalcoholic fatty liver disease (NAFLD), is a major health issue closely related to metabolic dysfunctions, affecting a quarter of the world's adult population. The association of COVID-19 with MAFLD has received increasing attention, as MAFLD is a potential risk factor for SARS-CoV-2 infection and severe COVID-19 symptoms. In this review, we provide an update on the interactions between COVID-19 and MAFLD and its underlying mechanisms.
新型冠状病毒病（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，已成为持续存在的全球卫生大流行病。自 2019 年以来，大流行继续对我们生活的方方面面产生深远影响，给所有社会带来巨大的健康和经济负担。随着我们对 COVID-19 的深入了解，从最初的呼吸道到后来的胃肠道和心血管系统，人们发现这种传染病涉及多个器官。代谢相关脂肪性肝病（MAFLD），前称非酒精性脂肪性肝病（NAFLD），是与代谢功能障碍密切相关的一个主要健康问题，影响着全球四分之一的成年人口。COVID-19 与 MAFLD 的相关性引起了越来越多的关注，因为 MAFLD 是 SARS-CoV-2 感染和严重 COVID-19 症状的潜在危险因素。在这篇综述中，我们提供了 COVID-19 和 MAFLD 之间相互作用及其潜在机制的最新信息。
