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《中国国家基本药物目录与治疗指南的一致性——以肿瘤药物为例》。

The Consistency Between the Chinese Essential Medicines List and Treatment Guidelines-Taking Oncology Medicines as an Example.

机构信息

School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.

The Research Center of National Drug Policy and Ecosystem, China Pharmaceutical University, Nanjing, China.

出版信息

Front Public Health. 2022 Jul 7;10:943994. doi: 10.3389/fpubh.2022.943994. eCollection 2022.

Abstract

The concepts of "essential medicine" and "national medicine policy" were first put forward for the first time at the World Health Assembly in 1975 in an effort to alleviate the problem of medicine unavailability in developing and poor countries. The essential medicine system in China has experienced three development stages since 1979, when the concept of essential medicines was first introduced, to actively respond to the call of the World Health Organization. Currently, the essential medicines list published in China is the national essential medicines list (2018 Edition). In this study, we examined the consistency between the essential medicines for treating seven cancers (liver cancer, breast cancer, esophageal cancer, lung cancer, colorectal cancer, gastric cancer, and leukemia) and the recommended medicines by cancer treatment guidelines to determine whether the essential medicines are of high quality for clinical needs. The results indicated that the degree of similarity between oncology medicines on the essential medicines list and oncology medicines recommended by guidelines was low, with the majority falling between 30 and 60%. Therefore, to improve the quality of essential medicines, it is necessary to further improve the matching degree. In addition, to further improve the consistency between the essential medicines list and treatment guidelines, the following suggestions are put forward in this paper: (1). Formulate universal treatment guidelines; (2). When selecting essential medicines, greater consideration should be given to those recommended in the guidelines; (3). The essential medicines list and treatment guidelines should be concurrently updated; (4). The cycle for updating the essential medicines list and treatment guidelines should be shortened.

摘要

“基本药物”和“国家药物政策”的概念于 1975 年在世界卫生大会上首次提出,旨在缓解发展中国家和贫困国家药品供应不足的问题。中国的基本药物制度自 1979 年首次引入基本药物概念以来,经历了三个发展阶段,积极响应了世界卫生组织的号召。目前,中国发布的基本药物目录是《国家基本药物目录(2018 年版)》。本研究考察了治疗七种癌症(肝癌、乳腺癌、食管癌、肺癌、结直肠癌、胃癌和白血病)的基本药物与癌症治疗指南推荐药物之间的一致性,以确定基本药物是否满足临床需求的高质量。结果表明,基本药物目录上的肿瘤药物与指南推荐的肿瘤药物之间的相似度较低,大部分在 30%至 60%之间。因此,要提高基本药物的质量,需要进一步提高匹配度。此外,为了进一步提高基本药物目录与治疗指南的一致性,本文提出以下建议:(1)制定通用治疗指南;(2)在选择基本药物时,应更多地考虑指南中推荐的药物;(3)基本药物目录和治疗指南应同时更新;(4)缩短基本药物目录和治疗指南的更新周期。

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