前列腺癌干细胞：临床方面与靶向治疗
Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies.
作者信息
Wolf Isis, Gratzke Christian, Wolf Philipp
机构信息
Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
出版信息
Front Oncol. 2022 Jul 8;12:935715. doi: 10.3389/fonc.2022.935715. eCollection 2022.
Abstract
Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.
摘要
尽管经过数十年的研究以及在诊断和治疗方面取得了成功进展，但前列腺癌（PC）仍然是一项重大挑战。近年来，越来越清楚的是，前列腺癌干细胞（PCSCs）是前列腺癌肿瘤发生、复发、转移和治疗抵抗的驱动力。在这篇小型综述中，我们讨论了前列腺癌干细胞在临床实践中的影响。此外，还介绍了对抗前列腺癌干细胞的新治疗方法，旨在为前列腺癌患者带来更好的治疗效果。
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