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Molecular mechanisms of docetaxel resistance in prostate cancer.前列腺癌中多西他赛耐药的分子机制
Cancer Drug Resist. 2020 Aug 21;3(4):676-685. doi: 10.20517/cdr.2020.37. eCollection 2020.
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Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment.用于去势抵抗性前列腺癌治疗的共包装多西他赛和雄激素受体小干扰RNA的PSMA靶向纳米系统的研发与评估
Pharmaceutics. 2022 Apr 29;14(5):964. doi: 10.3390/pharmaceutics14050964.
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Integrative Chinese-Western medicine strategy to overcome docetaxel resistance in prostate cancer.中西整合医学策略克服前列腺癌多西他赛耐药性。
J Ethnopharmacol. 2024 Sep 15;331:118265. doi: 10.1016/j.jep.2024.118265. Epub 2024 Apr 25.
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Targeting MRP4 expression by anti-androgen treatment reverses MRP4-mediated docetaxel resistance in castration-resistant prostate cancer.通过抗雄激素治疗靶向MRP4表达可逆转去势抵抗性前列腺癌中MRP4介导的多西他赛耐药性。
Oncol Lett. 2017 Aug;14(2):1748-1756. doi: 10.3892/ol.2017.6357. Epub 2017 Jun 8.
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Exploitation of the Androgen Receptor to Overcome Taxane Resistance in Advanced Prostate Cancer.雄激素受体的利用克服晚期前列腺癌中的紫杉烷耐药性。
Adv Cancer Res. 2015;127:123-58. doi: 10.1016/bs.acr.2015.03.001. Epub 2015 Mar 29.
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Overexpression of claspin promotes docetaxel resistance and is associated with prostate-specific antigen recurrence in prostate cancer.Claspin 的过表达促进多西他赛耐药，并与前列腺癌中前列腺特异性抗原的复发相关。
Cancer Med. 2021 Aug;10(16):5574-5588. doi: 10.1002/cam4.4113. Epub 2021 Jul 9.
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Comparison of Sequential Treatment With Androgen Receptor-Targeted Agent Followed by Another Androgen Receptor-Targeted Agent Versus Androgen Receptor-Targeted Agent Followed by Docetaxel in Chemotherapy-Naive Patients With Metastatic Castration-Resistant Prostate Cancer.在化疗初治的转移性去势抵抗性前列腺癌患者中，雄激素受体靶向药物序贯治疗与另一种雄激素受体靶向药物序贯治疗与多西他赛化疗的比较。
Clin Genitourin Cancer. 2017 Dec;15(6):e1073-e1080. doi: 10.1016/j.clgc.2017.07.016. Epub 2017 Jul 26.
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Comparison of Alternative Androgen Receptor-axis-targeted Agent (ARATA) and Docetaxel as Second-line Therapy for Patients With Metastatic Castration-resistant Prostate Cancer With Progression After Initial ARATA in Real-world Clinical Practice in Japan.比较在日本真实世界临床实践中，初始 ARATA 治疗后进展的转移性去势抵抗性前列腺癌患者二线治疗中替代雄激素受体轴靶向药物（ARATA）和多西他赛的疗效。
Clin Genitourin Cancer. 2018 Jun;16(3):219-225. doi: 10.1016/j.clgc.2017.11.007. Epub 2017 Dec 6.
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The clinical benefit of sequential therapy with androgen receptor axis-targeted agents alone in patients with castration-resistant prostate cancer: A propensity score-matched comparison study.雄激素受体轴靶向药物序贯治疗在去势抵抗性前列腺癌患者中的临床获益：一项倾向评分匹配比较研究。
Prostate. 2020 Nov;80(15):1373-1380. doi: 10.1002/pros.24069. Epub 2020 Sep 11.
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Docetaxel-carboxymethylcellulose nanoparticles display enhanced anti-tumor activity in murine models of castration-resistant prostate cancer.多西他赛-羧甲基纤维素纳米粒在去势抵抗性前列腺癌小鼠模型中显示出增强的抗肿瘤活性。
Int J Pharm. 2014 Aug 25;471(1-2):224-33. doi: 10.1016/j.ijpharm.2014.05.021. Epub 2014 May 20.
引用本文的文献
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Impact of adding carboplatin to docetaxel chemotherapy on testosterone levels and treatment outcomes in metastatic docetaxel-resistant prostate cancer.在多西他赛耐药的转移性前列腺癌中，卡铂联合多西他赛化疗对睾酮水平及治疗结果的影响
Sci Rep. 2025 Jun 20;15(1):20130. doi: 10.1038/s41598-025-04667-0.
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The role of the tumor microenvironment in HNSCC resistance and targeted therapy.肿瘤微环境在头颈部鳞状细胞癌耐药性及靶向治疗中的作用。
Front Immunol. 2025 Apr 1;16:1554835. doi: 10.3389/fimmu.2025.1554835. eCollection 2025.
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Curcumin and Its Potential to Target the Glycolytic Behavior of Lactate-Acclimated Prostate Carcinoma Cells with Docetaxel.姜黄素及其与多西他赛共同靶向乳酸适应型前列腺癌细胞糖酵解行为的潜力。
Nutrients. 2024 Dec 16;16(24):4338. doi: 10.3390/nu16244338.
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Snake venom toxins as potential therapeutic agents in the treatment of prostate cancer.蛇毒毒素作为治疗前列腺癌的潜在治疗剂。
Mol Biol Rep. 2024 Nov 14;51(1):1153. doi: 10.1007/s11033-024-09970-z.
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Therapy resistance in prostate cancer: mechanism, signaling and reversal strategies.前列腺癌中的治疗耐药性：机制、信号传导及逆转策略
Explor Target Antitumor Ther. 2024;5(5):1110-1134. doi: 10.37349/etat.2024.00266. Epub 2024 Aug 29.
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Docetaxel-Induced Cell Death Is Regulated by a Fatty Acid-Binding Protein 12-Slug-Survivin Pathway in Prostate Cancer Cells.多西他赛诱导的细胞死亡受脂肪酸结合蛋白 12- slug-survivin 通路调控在前列腺癌细胞。
Int J Mol Sci. 2024 Sep 6;25(17):9669. doi: 10.3390/ijms25179669.
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Failure to progress: breast and prostate cancer cell lines in developing targeted therapies.进展失败：开发靶向疗法的乳腺癌和前列腺癌细胞系。
Cancer Metastasis Rev. 2024 Dec;43(4):1529-1548. doi: 10.1007/s10555-024-10202-w. Epub 2024 Jul 26.
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Computer-aided drug discovery strategies for novel therapeutics for prostate cancer leveraging next-generating sequencing data.利用下一代测序数据的计算机辅助药物发现策略，为前列腺癌新型疗法提供新契机。
Expert Opin Drug Discov. 2024 Jul;19(7):841-853. doi: 10.1080/17460441.2024.2365370. Epub 2024 Jun 11.
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Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients.用于区分前列腺癌患者化疗敏感与化疗抵抗反应者的基因特征
Curr Issues Mol Biol. 2024 Mar 11;46(3):2263-2277. doi: 10.3390/cimb46030145.
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Anticancer Effect by Combined Treatment of L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells.白藜芦醇多酚与多西他赛联合治疗对DU145前列腺癌细胞和HCT116结肠癌细胞的抗癌作用
Curr Issues Mol Biol. 2024 Feb 19;46(2):1621-1634. doi: 10.3390/cimb46020105.
本文引用的文献
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Taxane resistance in prostate cancer is mediated by decreased drug-target engagement.紫杉醇耐药性在前列腺癌中是由药物靶标结合减少介导的。
J Clin Invest. 2020 Jun 1;130(6):3287-3298. doi: 10.1172/JCI132184.
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CD133 antibody targeted delivery of gold nanostars loading IR820 and docetaxel for multimodal imaging and near-infrared photodynamic/photothermal/chemotherapy against castration resistant prostate cancer.CD133 抗体靶向递呈载金纳米星的 IR820 和多西他赛用于去势抵抗性前列腺癌的多模式成像及近红外光动力/光热/化疗
Nanomedicine. 2020 Jul;27:102192. doi: 10.1016/j.nano.2020.102192. Epub 2020 Mar 27.
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Cellular rewiring in lethal prostate cancer: the architect of drug resistance.致命性前列腺癌中的细胞重排：耐药性的建筑师。
Nat Rev Urol. 2020 May;17(5):292-307. doi: 10.1038/s41585-020-0298-8. Epub 2020 Mar 16.
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Biomarkers of response to advanced prostate cancer therapy.晚期前列腺癌治疗反应的生物标志物。
Expert Rev Mol Diagn. 2020 Feb;20(2):195-205. doi: 10.1080/14737159.2020.1707669. Epub 2020 Jan 27.
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The stem cell inhibitor salinomycin decreases colony formation potential and tumor-initiating population in docetaxel-sensitive and docetaxel-resistant prostate cancer cells.干细胞抑制剂盐霉素可降低多西紫杉醇敏感和耐药前列腺癌细胞的集落形成能力和肿瘤起始细胞群体。
Prostate. 2020 Feb;80(3):267-273. doi: 10.1002/pros.23940. Epub 2019 Dec 13.
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Therapeutic Targeting of MDR1 Expression by RORγ Antagonists Resensitizes Cross-Resistant CRPC to Taxane via Coordinated Induction of Cell Death Programs.RORγ 拮抗剂通过协调诱导细胞死亡程序使多药耐药 1 表达的治疗靶向使交叉耐药性 CRPC 对紫杉烷类药物重新敏感。
Mol Cancer Ther. 2020 Feb;19(2):364-374. doi: 10.1158/1535-7163.MCT-19-0327. Epub 2019 Nov 11.
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Class III β-tubulin expression as a predictor of docetaxel-resistance in metastatic castration-resistant prostate cancer.III 类β-微管蛋白表达作为转移性去势抵抗性前列腺癌多西他赛耐药的预测因子。
PLoS One. 2019 Oct 28;14(10):e0222510. doi: 10.1371/journal.pone.0222510. eCollection 2019.
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Targeting the TMPRSS2/ERG fusion mRNA using liposomal nanovectors enhances docetaxel treatment in prostate cancer.利用脂质体纳米载体靶向 TMPRSS2/ERG 融合 mRNA 可增强前列腺癌的多西他赛治疗效果。
Prostate. 2020 Jan;80(1):65-73. doi: 10.1002/pros.23918. Epub 2019 Oct 15.
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TUBB3 Reverses Resistance to Docetaxel and Cabazitaxel in Prostate Cancer.TUBB3 逆转前列腺癌对多西他赛和卡巴他赛的耐药性。
Int J Mol Sci. 2019 Aug 13;20(16):3936. doi: 10.3390/ijms20163936.
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