Elsaygh Hassan, Alhafez Iman, Jaber Mohammed, Al-Rasheed Maice, Zaher Anas, ElSaygh Jude
Internal Medicine, University of Debrecen, Debrecen, HUN.
Cureus. 2022 Jun 19;14(6):e26092. doi: 10.7759/cureus.26092. eCollection 2022 Jun.
The most common reason for seeing a gastroenterologist is irritable bowel syndrome (IBS). IBS was thought to be a functional disease; however, there are now numerous alternative pathophysiologic pathways that can explain the symptoms. The pathophysiology of IBS is diverse and not well understood. Most current first-line treatments for IBS target the primary symptom and mainly impact one symptom in the symptom complex. The purpose of this study was to summarize the data on new medicines used to treat IBS. We conducted a bibliographic search in Google Scholar and PubMed focused on medication clinical trials in IBS with diarrhea. New medications for IBS with diarrhea target important pathways in the pathophysiology of these disorders, improving both the abnormal bowel habit and other significant symptoms such as abdominal pain and bloating.
看胃肠病专家最常见的原因是肠易激综合征（IBS）。IBS曾被认为是一种功能性疾病；然而，现在有许多其他病理生理途径可以解释这些症状。IBS的病理生理学是多样的，尚未被充分理解。目前大多数IBS的一线治疗针对主要症状，主要影响症状复合体中的一种症状。本研究的目的是总结用于治疗IBS的新药的数据。我们在谷歌学术和PubMed上进行了文献检索，重点关注IBS伴腹泻的药物临床试验。治疗IBS伴腹泻的新药针对这些疾病病理生理学中的重要途径，改善异常排便习惯以及腹痛和腹胀等其他重要症状。
