Hassler O
Am J Pathol. 1972 Sep;68(3):511-20.
Eight intracranial saccular aneurysms from 6 autopsies were studied with the scanning electron microscope and the cerebral arteries from control autopsies and rabbits were compared. The intima of the aneurysms had a more uneven and rugged surface than the surroundings. Only slight atherosclerotic changes were discovered in the immediate vicinity of the aneurysms. The windows of the internal elastic lamella were enlarged at the mouth of the aneurysms; the edge of the muscle layer was rounded and showed fibrosis. The structure of the walls of the aneurysms differed from that of the control arteries because they were composed of collagenous connective tissue. The adventitia of the aneurysms resembled that of control arteries. The findings are in accord with the assumption that saccular aneurysms develop at sites of developmental media defects. The internal elastic lamella over the area of the media defect shows primarily compensatory hypertrophy and later degeneration, extension and decay.
对6例尸检中的8个颅内囊状动脉瘤进行了扫描电子显微镜研究，并与对照尸检和兔子的脑动脉进行了比较。动脉瘤的内膜表面比周围更不均匀、更粗糙。仅在动脉瘤紧邻区域发现轻微的动脉粥样硬化改变。在动脉瘤开口处，内弹性膜的窗孔扩大；肌层边缘呈圆形并显示纤维化。动脉瘤壁的结构与对照动脉不同，因为它们由胶原结缔组织组成。动脉瘤的外膜与对照动脉的外膜相似。这些发现与囊状动脉瘤在发育性中膜缺损部位形成的假设一致。中膜缺损区域上方的内弹性膜主要表现为代偿性肥大，随后发生变性、延伸和衰退。
