Sohouli Mohammad Hassan, Baniasadi Mansoureh, Hernández-Ruiz Ángela, Melekoglu Ebru, Zendehdel Mona, José Soto-Méndez María, Akbari Atieh, Zarrati Mitra
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Cancer. 2023;75(1):164-173. doi: 10.1080/01635581.2022.2102658. Epub 2022 Jul 23.
We aimed to examine whether anthropometric indices, dietary factors, and nutrient intakes of women with and without breast cancer (BrCa) are associated with the oxidative balance score (OBS). This case-control study was carried out among 253 patients with BrCa and 267 healthy subjects aged >18 years. The OBS was calculated by using the following 13 dietary and non-dietary anti- and prooxidant components: dietary antioxidants (selenium, fiber, β-carotene, vitamin D, vitamin C, vitamin E, and folate), dietary prooxidants (iron and saturated and polyunsaturated fatty acids), and nondietary anti- (physical activity) and prooxidants (smoking and obesity). The binary logistic regression was used to determine the association OBS with BrCa. After adjusting for potential confounders in the final model, there was evidence that the odds of BrCa decreased with increasing categories of the OBS (OR = 0.53, 95% CI 0.28 - 0.98; P-trend = 0.021). When we made stratified analysis by menopausal status, OBS was inversely associated with odds of BrCa in premenopausal women after adjusting for potential confounders. No significant association was found between OBS and odds of BrCa among post-menopausal women. Our data suggest that OBS scores were associated with decreased BrCa risk in the overall population.
我们旨在研究患有和未患乳腺癌（BrCa）的女性的人体测量指标、饮食因素和营养摄入量是否与氧化平衡评分（OBS）相关。这项病例对照研究在253例BrCa患者和267名年龄大于18岁的健康受试者中进行。OBS通过以下13种饮食和非饮食抗氧化剂和促氧化剂成分计算得出：饮食抗氧化剂（硒、纤维、β-胡萝卜素、维生素D、维生素C、维生素E和叶酸）、饮食促氧化剂（铁以及饱和和多不饱和脂肪酸），以及非饮食抗氧化剂（身体活动）和促氧化剂（吸烟和肥胖）。采用二元逻辑回归来确定OBS与BrCa之间的关联。在最终模型中对潜在混杂因素进行调整后，有证据表明，BrCa的患病几率随着OBS类别增加而降低（OR = 0.53，95% CI 0.28 - 0.98；P趋势 = 0.021）。当我们按绝经状态进行分层分析时，在对潜在混杂因素进行调整后，OBS与绝经前女性患BrCa的几率呈负相关。在绝经后女性中，未发现OBS与BrCa几率之间存在显著关联。我们的数据表明，OBS评分与总体人群中BrCa风险降低相关。
