坚持生命线饮食评分（LLDS）与降低乳腺癌（BrCa）风险相关：一项病例对照研究。
Adherence to Lifelines Diet Score (LLDS) Is Associated with a Reduced Risk of Breast Cancer (BrCa): A Case-Control Study.
机构信息
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Int J Clin Pract. 2022 Feb 4;2022:7726126. doi: 10.1155/2022/7726126. eCollection 2022.
BACKGROUND
Previous evidence suggests a link between diet quality and breast cancer (BrCa); however, the link between the Lifelines Diet Score (LLDS)-a fully food-based score that uses the 2015 Dutch Dietary Guidelines-and risk of BrCa has not yet been evaluated. Therefore, the aim of this study was to observe the relationship between adherence to an LLDS and risk of BrCa in Iranian adults.
METHODS
In the hospital-based case-control study, 253 patients with BrCa and 267 non-BrCa controls were enrolled. Individual's food consumption was recorded to calculate LLDS using a semiquantitative food frequency questionnaire. In adjusted models, the association between the inflammatory potential of the diet and the risk of BrCa was estimated by using binary logistic regression.
RESULTS
Compared with control individuals, BrCa patients significantly had higher waist circumference (WC), first pregnancy age, abortion history, and number of children. In addition, the mean intake of vitamin supplements and anti-inflammatory drugs in the case group was significantly lower than the control group. Furthermore, after adjusted potential confounders, individuals in the highest vs. lowest quartiles of LLDS showed statistically significant lower risk of BrCa in overall population (OR: 0.21; 95% CI: 0.11-0.43; P trend <0.001), premenopausal (OR: 0.26; 95% CI: 0.10-0.68; P trend = 0.003), and post-menopausal women (OR: 0.20; 95% CI: 0.06-0.60; P trend = 0.015).
CONCLUSION
Findings of this study reflected that higher LLDS decreased risk of BrCa, but need further investigation in later studies.
背景
先前的证据表明饮食质量与乳腺癌（BrCa）之间存在关联；然而，Lifelines 饮食评分（LLDS）与 BrCa 风险之间的联系尚未得到评估，LLDS 是一个完全基于食物的评分，使用 2015 年荷兰膳食指南。因此，本研究旨在观察伊朗成年人中 LLDS 与 BrCa 风险之间的关系。
方法
在基于医院的病例对照研究中，纳入了 253 名 BrCa 患者和 267 名非 BrCa 对照者。使用半定量食物频率问卷记录个体的食物摄入量，以计算 LLDS。在调整后的模型中，使用二元逻辑回归估计饮食的炎症潜力与 BrCa 风险之间的关联。
结果
与对照组相比，BrCa 患者的腰围（WC）、初孕年龄、流产史和子女数量显著较高。此外，病例组中维生素补充剂和抗炎药物的平均摄入量明显低于对照组。此外，在调整了潜在混杂因素后，LLDS 最高四分位与最低四分位的个体在总体人群中显示出 BrCa 风险显著降低（OR：0.21；95%CI：0.11-0.43；P 趋势 <0.001），在绝经前（OR：0.26；95%CI：0.10-0.68；P 趋势=0.003）和绝经后女性（OR：0.20；95%CI：0.06-0.60；P 趋势=0.015）。
结论
本研究的结果表明，较高的 LLDS 降低了 BrCa 的风险，但需要进一步的后续研究。
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