Department of Dermatology, Virgen del Rocío University Hospital, Seville, Spain.
Department of Medicine, University of Seville, Seville, Spain.
Clin Exp Dermatol. 2022 Nov;47(11):1943-1950. doi: 10.1111/ced.15342. Epub 2022 Sep 16.
Systemic sclerosis (SSc) is an autoimmune chronic rheumatic disease with a high mortality rate, which continues to be a challenge for clinicians today.
To assess changes in mortality trends in the Spanish SSc population between 1980 and 2019, taking into account the independent effects of sex, age, time period and birth cohort.
SSc death records and mid-year population data were collected from the National Statistics Institute. Age-standardized mortality rates were calculated for the overall population and for each sex (male, female) and age group (5-year groups). Significant changes in mortality trends were identified by joinpoint regressions. An age-period-cohort (APC) analysis and potential years of life lost (PYLL) analysis were performed to identify the burden of SSc.
Age-standardized mortality rates due to SSc increased from 1.87 (95% CI 1.00-3.02) per 1 000 000 inhabitants between 1980 and 1984, to 2.47 (95% CI 1.74-3.02) per 1 000 000 inhabitants between 2015 and 2019. The relative risk of mortality fell in all groups in cohorts born after 1990. The PYLL rates showed a gradual rise for both sexes.
There was an increase in overall SSc mortality in Spain during the 39 years evaluated, although there was a progressive drop for men.
系统性硬化症（SSc）是一种高死亡率的自身免疫性慢性风湿性疾病，至今仍是临床医生面临的挑战。
评估 1980 年至 2019 年期间西班牙 SSc 人群死亡率趋势的变化，同时考虑性别、年龄、时间段和出生队列的独立影响。
从国家统计局收集 SSc 死亡记录和年中人口数据。计算了总人口以及每个性别（男性、女性）和年龄组（5 岁组）的年龄标准化死亡率。通过连接回归确定死亡率趋势的显著变化。进行年龄-时期-队列（APC）分析和潜在寿命损失（PYLL）分析，以确定 SSc 的负担。
1980 年至 1984 年期间，SSc 导致的年龄标准化死亡率从每 100 万居民 1.87（95%CI 1.00-3.02）增加到 2015 年至 2019 年期间的每 100 万居民 2.47（95%CI 1.74-3.02）。在所有队列中，出生于 1990 年后的人群的死亡率相对风险均下降。男女的潜在寿命损失率均呈逐渐上升趋势。
在评估的 39 年间，西班牙的 SSc 总死亡率呈上升趋势，尽管男性的死亡率呈逐渐下降趋势。
