Yen Duong Thi Hai, Lan Hoang Thi Tuyet, Anh Bui Thi Mai, Van Kiem Phan, Tai Bui Huu, Huyen Le Thi, Yen Pham Hai, Nhiem Nguyen Xuan, Mai Nguyen Thi
Institute of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi 10072, Vietnam.
Faculty of Basic Sciences, University of Transport and Communications, Hanoi 11512, Vietnam.
J Asian Nat Prod Res. 2023 May;25(5):510-517. doi: 10.1080/10286020.2022.2098728. Epub 2022 Jul 25.
A new furostane saponin, ramosaponin (), and four known furostane saponins, protodioscin (), dehydrotomatoside (), (25 )-26--(-D-glucopyranosyl)-furost-5-ene-3,22,26-triol 3---D-glucopyranosyl-(1→4)--D-galactopyranoside (), and anguivioside A () were isolated from the methanol extract of seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell line. As a result, compound showed significant lipid accumulation inhibitory activity with an IC value of 64.32 ± 3.87 µM.
从种子的甲醇提取物中分离出一种新的呋甾烷皂苷——拉莫皂苷（），以及四种已知的呋甾烷皂苷——原薯蓣皂苷（）、脱氢番茄苷（）、（25）-26-（-D-吡喃葡萄糖基）-呋甾-5-烯-3,22,26-三醇3---D-吡喃葡萄糖基-（1→4）--D-吡喃半乳糖苷（）和鳗鲡皂苷A（）。根据光谱证据并与文献报道的结构进行比较确定了它们的结构。对所有化合物进行了在HepG2细胞系中减少脂质积累的评估。结果，化合物显示出显著的脂质积累抑制活性，IC值为64.32±3.87μM。
