从薤白中分离得到的两种新甾体皂苷及其对不同癌细胞系的细胞毒性
Two new steroidal saponins from Allium macrostemon bunge and their cytotoxity on different cancer cell lines.
作者信息
Chen Hai-Feng, Wang Guang-Hui, Luo Qiang, Wang Nai-Li, Yao Xin-Sheng
机构信息
Institute for Biomedical Research, Xiamen University, Xiamen 361005, China.
出版信息
Molecules. 2009 Jun 19;14(6):2246-53. doi: 10.3390/molecules14062246.
Two new steroidal saponins (1 and 2) were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated by the spectral data as 26-O-beta-D-glucopyranosyl-5alpha-furost-25 (27)-ene-3beta, 12beta, 22, 26-tetraol-3-O-beta-D-glucopyranosyl (1-->2) [beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl (1-->4)-beta-D-galactopyranoside (1) and 26-O-beta-D-glucopyranosyl-5beta-furost-20 (22)-25 (27)-dien-3beta, 12beta, 26-triol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (2), respectively. Their cytotoxic activities on several cancer cell lines (MCF-7, NCI-H460, SF-268 and HepG2) were tested. 1 showed special cytotoxity on SF-268, while 2 showed cytotoxity on NCI-H460 and SF-268 cell lines, respectively.
从薤白干燥鳞茎中分离得到两个新的甾体皂苷（1和2）。通过光谱数据确定它们的结构分别为26 - O - β - D - 吡喃葡萄糖基 - 5α - 呋甾 - 25（27）- 烯 - 3β，12β，22，26 - 四醇 - 3 - O - β - D - 吡喃葡萄糖基（1→2）[β - D - 吡喃葡萄糖基（1→3）] - β - D - 吡喃葡萄糖基（1→4）- β - D - 吡喃半乳糖苷（1）和26 - O - β - D - 吡喃葡萄糖基 - 5β - 呋甾 - 20（22）- 25（27）- 二烯 - 3β，12β，26 - 三醇 - 3 - O - β - D - 吡喃葡萄糖基（1→2）- β - D - 吡喃半乳糖苷（2）。测试了它们对几种癌细胞系（MCF - 7、NCI - H460、SF - 268和HepG2）的细胞毒性活性。1对SF - 268表现出特殊的细胞毒性，而2分别对NCI - H460和SF - 268细胞系表现出细胞毒性。
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