Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, 10072, Vietnam.
Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, 10072, Vietnam.
Chem Biodivers. 2022 Sep;19(9):e202200590. doi: 10.1002/cbdv.202200590. Epub 2022 Sep 7.
Three new furostane saponins, ramofurosides A-C (1-3), and two known saponins, fistulosaponin B (4) and (25R)-26-O-β-D-glucopyranosyl-1β,3β,26-trihydroxyfurosta-5,20(22)-diene-1-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside (5) were isolated from the methanol extract of Allium ramosum seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell lines. As a result, compounds 1 and 3 showed a significant reduction in total lipid content by 27.93±3.05 and 27.54±1.68 %, respectively, at a concentration of 100 μM.
从葱属植物种子的甲醇提取物中分离得到三种新的呋甾烷皂苷，即 ramofurosides A-C（1-3），以及两种已知的皂苷，即 fistulosaponin B（4）和（25R）-26-O-β-D-吡喃葡萄糖基-1β,3β,26-三羟基呋甾-5,20(22)-二烯-1-O-α-L-鼠李吡喃糖基-(1→2)-α-L-阿拉伯吡喃糖苷（5）。基于光谱证据和与文献报道的化合物的比较，确定了它们的结构。所有化合物均评估了其在 HepG2 细胞系中减少脂质积累的能力。结果表明，化合物 1 和 3 在 100 μM 浓度下，总脂质含量分别显著降低了 27.93±3.05%和 27.54±1.68%。
