Bioque Miquel, Catarina Matias-Martins Ana, Llorca-Bofí Vicent, Mezquida Gisela, Cuesta Manuel J, Vieta Eduard, Amoretti Sílvia, Lobo Antonio, González-Pinto Ana, Moreno Carmen, Roldán Alexandra, Martinez-Aran Anabel, Baeza Immaculada, Bergé Daniel, García-Rizo Clemente, Mas Herrero Sergi, Bernardo Miquel
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Schizophr Bull. 2022 Nov 18;48(6):1327-1335. doi: 10.1093/schbul/sbac089.
A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful to characterize this systemic inflammation state.
This study evaluated the NLR in a cohort of 310 subjects with a first episode of psychosis (FEP) and a matched group of 215 healthy controls, recruited in 16 Spanish centers participating in the PEPs Project. We investigated the NLR measures over 2 years in a prospective, naturalistic study.
At baseline, the FEP group showed a significant higher mean NLR compared to the control group (1.96 ± 1.11 vs 1.72 ± 0.74, P = 0.03). These ratio differences between groups grew at the 24 months follow-up visit (2.04 ± 0.86 vs 1.65 ± 0.65, P < 0.001). Within the FEP group, there were no significant differences in NLR across the follow-up visits, between genders or diagnosis groups (affective vs nonaffective). NLR values did not correlate with the Positive and Negative Symptoms Scale scores. The group of patients who did not reach remission criteria at the end of the study showed a significant higher NLR than those who remitted (2.1896 ± 0.85 vs 1.95 ± 0.87, P = 0.042). A significant correlation between antipsychotic doses and NLR was found at the two-years follow-up visit (r=0.461, P < 0.001).
Our results highlight the existence of an underlying predisposition of FEP patients to present an increased mean NLR. The use of NLR in clinical practice could be helpful to identify this inflammatory imbalance.
促炎表型与精神障碍有关。中性粒细胞与淋巴细胞比值（NLR）是一种易于获取的生物标志物，可能有助于表征这种全身炎症状态。
本研究评估了参与PEPs项目的16个西班牙中心招募的310例首发精神病（FEP）患者队列和215例匹配的健康对照者的NLR。我们在一项前瞻性、自然主义研究中对NLR指标进行了2年的调查。
在基线时，FEP组的平均NLR显著高于对照组（1.96±1.11 vs 1.72±0.74，P = 0.03）。两组之间的这些比值差异在24个月的随访中增大（2.04±0.86 vs 1.65±0.65，P < 0.001）。在FEP组内，随访期间、不同性别或诊断组（情感性与非情感性）之间的NLR无显著差异。NLR值与阳性和阴性症状量表评分无关。在研究结束时未达到缓解标准的患者组的NLR显著高于缓解的患者组（2.1896±0.85 vs 1.95±0.87，P = 0.042）。在两年随访时发现抗精神病药物剂量与NLR之间存在显著相关性（r = 0.461，P < 0.001）。
我们的结果突出了FEP患者存在平均NLR升高的潜在易感性。在临床实践中使用NLR可能有助于识别这种炎症失衡。
