Northern Adelaide Local Health Network, Australia.
Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Australia.
Australas Psychiatry. 2020 Aug;28(4):454-458. doi: 10.1177/1039856220908172. Epub 2020 Mar 15.
A narrative review to describe the utility of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker in psychiatric and non-psychiatric disorders and to discuss the potential role of NLR in psychiatric research.
NLR is inexpensive and readily available using division of two measures obtained on routine blood testing. NLR is elevated in a number of psychiatric disorders. It can predict morbidity and mortality in a wide range of non-psychiatric conditions, but this has not been confirmed in psychiatric conditions. It can be calculated in large, pre-existing datasets to investigate clinical correlates of inflammatory processes. NLR may have a future role in identifying patients with an inflammatory phenotype who could benefit from adjunctive anti-inflammatory medications.
本文通过叙述性综述来描述中性粒细胞与淋巴细胞比值（NLR）作为一种炎症标志物在精神疾病和非精神疾病中的应用，并讨论 NLR 在精神疾病研究中的潜在作用。
NLR 是一种经济且易于使用的指标，可通过对常规血液检测中两个指标的划分来获得。许多精神疾病患者的 NLR 升高。NLR 在广泛的非精神疾病中可预测发病率和死亡率，但在精神疾病中尚未得到证实。它可以在大型的现有数据集进行计算，以研究炎症过程的临床相关性。NLR 可能在识别具有炎症表型的患者方面具有未来的作用，这些患者可能受益于辅助抗炎药物治疗。
