Cancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, 71516, Egypt.
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Infection. 2023 Feb;51(1):203-211. doi: 10.1007/s15010-022-01878-9. Epub 2022 Jul 25.
Leukemia patients are immune-compromised even before starting chemotherapy because the malignant cells invade the bone marrow and destroy WBC precursors. Leukemic patients are more susceptible to infection by a wide range of microorganisms. Viral infections and reactivations are common and may result in severe complications. The aim of this study is to investigate different causes of viremia in ALL pediatric patients as well as the clinical and the laboratory characteristics associated with viral infections.
Qualitative real-time PCR was used to detect (polyoma BK, parvo B19 and herpes simplex virus) DNA in the blood of ALL patients and routine hospital records were used to provide the data of hepatitis B & C virus infection.
Polyoma BK was the most common detected virus (51.2%) followed by herpes simplex (30.2%). Viremia by single virus was found in 16 (37.2%) cases, while viremia by multiple viruses was found in 15 (34.8%) cases. The most frequent co-detected viruses were herpes simplex and polyoma BK (11.6%) followed by herpes simplex, parvo B19 and polyoma BK (9.3%).
There is a high frequency of viremia by single virus and viremia by multiple viruses at the time of diagnosis of acute lymphoblastic leukemia in pediatric patients admitted to South Egypt Cancer Institute (SECI) compared to studies in other regions. Polyoma BK is the most common detected virus and is mainly associated with lymphopenia. It was also significantly associated with herpes simplex viremia. HCV infection was associated with increased incidence of CNS leukemia.
白血病患者在开始化疗之前就已经免疫功能受损，因为恶性细胞浸润骨髓并破坏白细胞前体。白血病患者更容易受到各种微生物的感染。病毒感染和再激活很常见，可能导致严重的并发症。本研究旨在调查 ALL 儿科患者血液中病毒血症的不同原因，以及与病毒感染相关的临床和实验室特征。
使用实时定量 PCR 检测 ALL 患者血液中的（多瘤 BK、细小 B19 和单纯疱疹病毒）DNA，并使用常规医院记录提供乙型和丙型肝炎病毒感染的数据。
多瘤 BK 是最常见的检测到的病毒（51.2%），其次是单纯疱疹病毒（30.2%）。16 例（37.2%）为单一病毒血症，15 例（34.8%）为多种病毒血症。最常见的共同检测到的病毒是单纯疱疹病毒和多瘤 BK（11.6%），其次是单纯疱疹病毒、细小 B19 和多瘤 BK（9.3%）。
与其他地区的研究相比，在埃及南部癌症研究所（SECI）就诊的急性淋巴细胞白血病儿科患者在诊断时，单一病毒和多种病毒血症的发生率较高。多瘤 BK 是最常见的检测到的病毒，主要与淋巴细胞减少症相关。它也与单纯疱疹病毒血症显著相关。HCV 感染与 CNS 白血病的发生率增加有关。
