Rat Patrice, Leproux Pascale, Fouyet Sophie, Olivier Elodie
Faculty of Pharmaceutical Sciences and Biology, Université Paris Cité, CNRS, CiTCoM, 75006 Paris, France.
Léa Nature, 17180 Périgny, France.
Toxics. 2022 Jun 30;10(7):355. doi: 10.3390/toxics10070355.
Forskolin, used in folk medicine since ancient times, is now available as a dietary supplement, with an indication as a fat burner and appetite suppressant. However, the safety of forskolin is poorly documented especially for pregnant women. The question that we raised is what about the safety of forskolin in pregnant women? As the placenta, an endocrine organ, is the key organ of pregnancy, we evaluated the in vitro placental toxicity of forskolin. We focused first on the activation of a P2X7 degenerative receptor as a key biomarker for placental toxicity, and second on steroid and peptide hormonal secretion. We observed that forskolin activated P2X7 receptors and disturbed estradiol, progesterone, hPL and hyperglycosylated hCG secretion in human placental JEG-Tox cells. To the best of our knowledge, we highlighted, for the first time, that forskolin induced endocrine disturbance in placental cells. Forskolin does not appear to be a safe product for pregnant women and restrictions should be taken.
毛喉素自古以来就被用于民间医学，现在作为一种膳食补充剂上市，具有脂肪燃烧剂和食欲抑制剂的功效。然而，毛喉素的安全性尤其是对孕妇的安全性记录甚少。我们提出的问题是，毛喉素对孕妇的安全性如何？由于胎盘作为一个内分泌器官，是妊娠的关键器官，我们评估了毛喉素的体外胎盘毒性。我们首先关注P2X7退化受体的激活，将其作为胎盘毒性的关键生物标志物，其次关注类固醇和肽类激素的分泌。我们观察到，毛喉素激活了人胎盘JEG-Tox细胞中的P2X7受体，并干扰了雌二醇、孕酮、人胎盘催乳素和高糖基化人绒毛膜促性腺激素的分泌。据我们所知，我们首次强调毛喉素会引起胎盘细胞的内分泌紊乱。毛喉素对孕妇似乎不是一种安全的产品，应该加以限制。
