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用从……分离的化合物治疗感染……的BALB/c小鼠后的治疗效果及免疫变化

Therapeutic Effect and Immune Changes after Treatment of -Infected BALB/c Mice with Compounds Isolated from .

作者信息

Ma Yi-Hsuan, Chen Chung-Yi, Chung Li-Yu, Yen Chuan-Min, Juan Yung-Shun, Lin Rong-Jyh

机构信息

Department of Parasitology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

出版信息

Vet Sci. 2022 Jul 18;9(7):368. doi: 10.3390/vetsci9070368.

DOI:10.3390/vetsci9070368
PMID:35878385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9316369/
Abstract

BACKGROUND/PURPOSE: is globally distributed. has been studied as a treatment, including the nematodes and protozoa, but no research results are related to cestodes. Therefore, the aim of this study was to target .

METHODS

The natural components of were isolated and added to which was cultured in vitro, to observe changes in the mortality, motility, and morphology. BALB/c male mice infected with were treated with effective components of for 10 days, and the changes were recorded. After the mice were sacrificed, the spleen weight was measured, and a primary culture was performed for the subsequent cytokine and chemokine testing.

RESULTS

The experiment found that 13-hydroxy-(13-S)-pheophytin a and aristophyll-C have clear cestocidal effects in vitro. 13-hydroxy-(13-S)-pheophytin a has been shown to be effective at reducing parasite populations and eliciting host immune responses in vivo. IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, MCP-1, IFN-γ, TNF-α, MIP-1α, and GM-CSF in 13-hydroxy-(13-S)-pheophytin a were significantly increased after stimulation, while IL-1α, IL-1β, IL-3, IL-12p70, and RANTES were unchanged.

CONCLUSIONS

The investigation shows that components of have actual cestocidal activity against .

摘要

背景/目的：[物质名称]在全球广泛分布。它已作为一种治疗手段进行研究，包括对线虫和原生动物，但尚无与绦虫相关的研究结果。因此，本研究的目的是针对[物质名称]。

方法

分离[物质名称]的天然成分并添加到体外培养的[寄生虫名称]中，观察其死亡率、活力和形态的变化。用[物质名称]的有效成分对感染[寄生虫名称]的BALB/c雄性小鼠进行为期10天的治疗，并记录变化情况。小鼠处死后，测量脾脏重量，并进行原代培养以进行后续的细胞因子和趋化因子检测。

结果

实验发现13-羟基-（13-S）-脱镁叶绿酸a和阿里斯托菲林-C在体外具有明显的杀绦虫作用。已证明13-羟基-（13-S）-脱镁叶绿酸a在体内可有效减少寄生虫数量并引发宿主免疫反应。刺激后，13-羟基-（13-S）-脱镁叶绿酸a中的IL-2、IL-4、IL-5、IL-6、IL-10、IL-13、IL-17、MCP-1、IFN-γ、TNF-α、MIP-1α和GM-CSF显著增加，而IL-1α、IL-1β、IL-3、IL-12p70和RANTES不变。

结论

研究表明，[物质名称]的成分对[寄生虫名称]具有实际的杀绦虫活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/9cebb5ca0f45/vetsci-09-00368-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/a3419ae81d4d/vetsci-09-00368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/8eebcf3f7971/vetsci-09-00368-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/fd48b0456753/vetsci-09-00368-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/56d983bee3ca/vetsci-09-00368-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/a9c5dce29693/vetsci-09-00368-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/cf4a79df7738/vetsci-09-00368-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/b8c93f3ca6e7/vetsci-09-00368-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/37c7f5378697/vetsci-09-00368-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/9cebb5ca0f45/vetsci-09-00368-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/a3419ae81d4d/vetsci-09-00368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/8eebcf3f7971/vetsci-09-00368-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/fd48b0456753/vetsci-09-00368-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/56d983bee3ca/vetsci-09-00368-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/a9c5dce29693/vetsci-09-00368-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/cf4a79df7738/vetsci-09-00368-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/b8c93f3ca6e7/vetsci-09-00368-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/37c7f5378697/vetsci-09-00368-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfb/9316369/9cebb5ca0f45/vetsci-09-00368-g009.jpg

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