Tsukahara Y, Ogura Y, Miura M, Kondo T
Ophthalmologica. 1987;194(1):27-33. doi: 10.1159/000309730.
The breakdown and repair of the blood-retinal barrier following argon laser photocoagulation were studied in pigmented rabbits by kinetic vitreous fluorophotometry using carboxyfluorescein as a tracer. The outward carboxyfluorescein transport across the blood-retinal barrier was significantly reduced in the photocoagulated eyes (p less than 0.01). This transport activity was normalized in 14 days. Ten rabbits were intraperitoneally pretreated with 0.1 M/kg probenecid, a competitive inhibitor, which was likely to decrease active transport across the outer blood-retinal barrier. In probenecid-treated animals, argon laser photocoagulation did not affect the permeability of the blood-retinal barrier. The present study suggests that some beneficial effects of photocoagulation may be attributed to replacement of diseased retinal pigment epithelium by rapid growth of new pigment epithelial cells and reestablishment of active transport across the restored barrier.
采用羧基荧光素作为示踪剂，运用动态玻璃体荧光光度测定法，对色素兔氩激光光凝术后血视网膜屏障的破坏及修复情况进行了研究。光凝眼内羧基荧光素跨血视网膜屏障的外向转运显著降低（p<0.01）。这种转运活性在14天内恢复正常。10只兔子腹腔内预先注射0.1M/kg丙磺舒，一种竞争性抑制剂，其可能会降低跨外血视网膜屏障的主动转运。在丙磺舒处理的动物中，氩激光光凝并未影响血视网膜屏障的通透性。本研究表明，光凝的一些有益作用可能归因于新色素上皮细胞的快速生长替代病变的视网膜色素上皮，以及跨修复屏障的主动转运的重新建立。
