Jaccoma E H, Conway B P, Campochiaro P A
Arch Ophthalmol. 1985 Nov;103(11):1728-30. doi: 10.1001/archopht.1985.01050110124039.
Using computerized vitreous fluorophotometry (VFP) in pigmented rabbits, we examined two modalities frequently used in retinal reattachment surgery, cryotherapy and argon laser photocoagulation, for their effect on the blood-retinal barrier. The VFP readings were taken 2 mm posterior to the lens one hour after intravenous injection of 14 mg/kg of fluorescein sodium. After baseline fluorophotometry readings, rabbits were treated with confluent cryotherapy over the inferior 180 degrees in one eye and with confluent laser over an equivalent area of retina in the other eye. The VFP readings were taken 2, 4, 6, and 15 days after treatment. By day 6, the VFP reading had risen from a pretreatment value of 6.4 +/- 0.4 ng/mL to 41.8 +/- 7.9 ng/mL in the cryotherapy-treated eyes as opposed to 15.5 +/- 3.1 ng/mL in the laser-treated eyes. By day 15, the readings were almost back to baseline, and there was no significant difference between the two treatment groups. These data suggest that there is a significant breakdown of the blood-retinal barrier with both modalities, but that it is considerably more severe with cryotherapy.
我们在有色家兔身上使用计算机化玻璃体荧光光度测定法（VFP），研究了视网膜复位手术中常用的两种方法——冷冻疗法和氩激光光凝术对血视网膜屏障的影响。在静脉注射14mg/kg荧光素钠一小时后，于晶状体后方2mm处进行VFP读数。在进行基线荧光光度测定读数后，一只眼睛对下方180度区域进行融合冷冻疗法治疗，另一只眼睛对视网膜相同面积区域进行融合激光治疗。在治疗后第2、4、6和15天进行VFP读数。到第6天，冷冻疗法治疗的眼睛中VFP读数从治疗前的6.4±0.4ng/mL升至41.8±7.9ng/mL，而激光治疗的眼睛中为15.5±3.1ng/mL。到第15天，读数几乎恢复到基线水平，两个治疗组之间没有显著差异。这些数据表明，两种方法都会导致血视网膜屏障明显破坏，但冷冻疗法导致的破坏要严重得多。
