Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Center for Advanced Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago 8380492, Chile.
Trends Mol Med. 2022 Oct;28(10):836-849. doi: 10.1016/j.molmed.2022.06.007. Epub 2022 Jul 22.
With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to explore non-conventional therapeutic measures to alleviate the burden of CVD on global healthcare. Mitochondrial injury plays a cardinal role in the pathogenesis of CVD. Mitochondrial dynamics and mitophagy are essential machineries that govern mitochondrial health in cardiomyocytes in physiological and pathophysiological settings. However, with the onset and progression of CVD, homeostasis of mitophagy is disturbed through largely unknown pathological mechanisms, causing mitochondrial damage and ultimately cardiomyocyte death. In this review we decipher the dual regulatory role of mitophagy in CVD pathogenesis, summarize controversies in mitophagy, and highlight recently identified compounds capable of modulating mitophagy. We share our perspectives on future mitophagy research directions in the context of CVD.
随着心血管疾病（CVD）的患病率不断上升，迫切需要探索非传统的治疗措施来减轻 CVD 给全球医疗保健带来的负担。线粒体损伤在 CVD 的发病机制中起着关键作用。线粒体动力学和线粒体自噬是在生理和病理生理条件下控制心肌细胞中线粒体健康的必要机制。然而，随着 CVD 的发生和发展，线粒体自噬的动态平衡通过尚不清楚的病理机制被打乱，导致线粒体损伤，最终导致心肌细胞死亡。在这篇综述中，我们揭示了线粒体自噬在 CVD 发病机制中的双重调节作用，总结了线粒体自噬中的争议，并强调了最近发现的能够调节线粒体自噬的化合物。我们分享了我们对 CVD 背景下线粒体自噬研究方向的看法。
