Rahman Ziaur, Dandekar Manoj P
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.
Neuromolecular Med. 2023 Mar;25(1):14-26. doi: 10.1007/s12017-022-08722-1. Epub 2022 Jul 25.
Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are major age-related concerns in elderly people. Since no drug fully addresses the progression of neurodegenerative diseases, advance treatment strategies are urgently needed. Several studies have noted the senescence of immune system and the perturbation of gut microbiota in the aged population. In recent years, the role of gut microbiota has been increasingly studied in the manifestation of age-related CNS disorders. In this context, prebiotics, probiotics, and paraprobiotics are reported to improve the behavioural and neurobiological abnormalities in elderly patients. As live microbiota, prescribed in the form of probiotics, shows some adverse effects like sepsis, translocation, and horizontal gene transfer, paraprobiotics could be a possible alternative strategy in designing microbiome-based therapeutics. This review describes the health-beneficial effects of paraprobiotics in age-associated neurodegenerative diseases.
神经退行性疾病，包括阿尔茨海默病和帕金森病，是老年人主要的与年龄相关的问题。由于没有药物能完全解决神经退行性疾病的进展问题，因此迫切需要先进的治疗策略。多项研究指出老年人群中免疫系统的衰老和肠道微生物群的紊乱。近年来，肠道微生物群在与年龄相关的中枢神经系统疾病表现中的作用得到了越来越多的研究。在这种背景下，据报道益生元、益生菌和准益生菌可改善老年患者的行为和神经生物学异常。由于以益生菌形式开具的活微生物群会表现出一些不良影响，如败血症、易位和水平基因转移，因此准益生菌可能是设计基于微生物群的疗法的一种替代策略。这篇综述描述了准益生菌在与年龄相关的神经退行性疾病中的健康有益作用。
