Lv Yingbin, Li Peiyuan, Su Rixiang, Cai Jinyun, Zhong Haiyi, Wen Fangzhou, Su Wei
College of Pharmacy, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, China.
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, China.
Photochem Photobiol. 2023 Jan;99(1):92-100. doi: 10.1111/php.13680. Epub 2022 Aug 9.
Photodynamic therapy and photothermal therapy provide new ways to combat antibiotic resistance. In this research, methylene blue (MB) as an effective photosensitizer was conjugated with carbon quantum dots (CQDs), the composite product not only possessed good antibacterial properties against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) due to excellent singlet oxygen ( O ) production rate and light heat transfer performance, but also showed good biocompatibility. Combined with 808 nm and 660 nm laser irradiation, the minimum bactericidal concentration of CQDs-MB towards S. aureus and E. coli was 5 μm. Therefore, this study provides a potential candidate material based on CQDs for clinical applications.
光动力疗法和光热疗法为对抗抗生素耐药性提供了新途径。在本研究中，将作为有效光敏剂的亚甲蓝（MB）与碳量子点（CQDs）共轭，该复合产物不仅由于出色的单线态氧（O）产生率和光热传递性能而对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）具有良好的抗菌性能，而且还表现出良好的生物相容性。结合808 nm和660 nm激光照射，CQDs-MB对金黄色葡萄球菌和大肠杆菌的最低杀菌浓度为5μm。因此，本研究为临床应用提供了一种基于碳量子点的潜在候选材料。
