Khamesipour Faham, Pourmohammad Amirhossein, Jafarian-Dehkordi Mohsen
Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Interdiscip Perspect Infect Dis. 2022 Jul 16;2022:6091834. doi: 10.1155/2022/6091834. eCollection 2022.
is a common parasitic disease with a cosmopolitan prevalence, causing severe health problems. Although chemotherapy for toxoplasmosis is readily available, most have side effects.
This study assesses the essential oil against activity, the anti- effects of essential oils with different concentrations were evaluated.
In the present study, RH strain tachyzoites were exposed to essential oil, and their viability effect on the parasite was evaluated. The viability test of tachyzoites was performed by using the staining method trypan blue . The inhibitory effect of extract on RH strain tachyzoites in the Vero cell line was evaluated.
has valuable efficacy , outperforming pyrimethamine and sulfadiazine at 30 and 90 minutes after exposure ( < 0.05). essential oil showed anti- activity in the cell line (IC50: 241.7 g/mL). After -infected Vero cells had been incubated with different concentrations of the essential oil, their viability decreased in a dose-dependent manner.
In conclusion, extract as an herbal medicine might be a valuable alternative to routine chemotherapy for toxoplasmosis.
是一种常见的寄生虫病，在全球范围内流行，会引发严重的健康问题。虽然针对弓形虫病的化疗药物很容易获得，但大多数都有副作用。
本研究评估了 精油对 活性的影响，对不同浓度精油的抗 作用进行了评估。
在本研究中，将 RH 株速殖子暴露于 精油中，并评估其对寄生虫的生存力影响。速殖子的生存力测试采用台盼蓝染色法进行。评估了 提取物对 Vero 细胞系中 RH 株速殖子的抑制作用。
具有显著疗效，在暴露后 30 分钟和 90 分钟时优于乙胺嘧啶和磺胺嘧啶（<0.05）。 精油在细胞系中显示出抗 活性（IC50：241.7 μg/mL）。感染 的 Vero 细胞与不同浓度的 精油孵育后，其生存力呈剂量依赖性下降。
总之， 提取物作为一种草药，可能是弓形虫病常规化疗的一种有价值的替代方法。
需注意，原文中部分关键信息缺失，导致译文存在信息不完整的情况。
