Zhang Wen-Yi, Nan Nan, He Yi, Zuo Hui-Juan, Song Xian-Tao, Zhang Min, Zhou Yuan
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Psychol Health Med. 2023 Jun;28(5):1275-1287. doi: 10.1080/13548506.2022.2104885. Epub 2022 Jul 25.
This study aimed to assess the prevalence of depression and anxiety in CHD patients and to explore the association between established cardiovascular risk factors and depression as well as anxiety. 2,216 patients with CHD confirmed by angiography were included in this cross-sectional study. Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7) were used to assess depression and anxiety symptoms. The frequencies of individual depressive and anxiety symptoms grouped by age and gender were analyzed. Binary logistic regression analyses were used to identify cardiovascular risk factors associated with anxiety and depression. The overall prevalence rates of depression and anxiety in CHD patients were 8.2% and 5.4%, respectively. There were significant differences in the frequency of depression and anxiety symptoms between genders. However, age differences among individual depression and anxiety symptoms were insignificant. In multivariable analysis, female gender, smoking, and hyperlipidemia were associated with a more frequent depression occurrence, and female gender was associated with more frequent anxiety. Depression and anxiety were not associated with other cardiovascular risk factors. These findings suggest that a substantial proportion of CHD patients experienced anxiety and depression symptoms. Differences in depressive or anxiety symptoms among the distribution of individual symptoms need more attention. Depression was significantly associated with female gender, smoking, and hyperlipidemia. No anxiety symptom associations with cardiovascular risk factors were demonstrated to be significant except for the female. More research is needed to unravel the mechanisms of depression, anxiety, and cardiovascular disease.
本研究旨在评估冠心病患者中抑郁和焦虑的患病率，并探讨既定心血管危险因素与抑郁以及焦虑之间的关联。本横断面研究纳入了2216例经血管造影确诊的冠心病患者。采用患者健康问卷（PHQ - 9）和广泛性焦虑障碍量表（GAD - 7）评估抑郁和焦虑症状。分析了按年龄和性别分组的个体抑郁和焦虑症状的频率。采用二元逻辑回归分析来确定与焦虑和抑郁相关的心血管危险因素。冠心病患者中抑郁和焦虑的总体患病率分别为8.2%和5.4%。抑郁和焦虑症状的频率在性别之间存在显著差异。然而，个体抑郁和焦虑症状在年龄上的差异不显著。在多变量分析中，女性、吸烟和高脂血症与更频繁的抑郁发生相关，女性与更频繁的焦虑相关。抑郁和焦虑与其他心血管危险因素无关。这些发现表明，相当一部分冠心病患者经历了焦虑和抑郁症状。个体症状分布中抑郁或焦虑症状的差异需要更多关注。抑郁与女性、吸烟和高脂血症显著相关。除女性外，未证明焦虑症状与心血管危险因素之间存在显著关联。需要更多研究来阐明抑郁、焦虑和心血管疾病的机制。
