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[抗癌药物所致间质性肺疾病诊治专家共识]

[Expert consensus on the diagnosis and treatment of anticancer drug-induced interstitial lung disease].

出版信息

Zhonghua Zhong Liu Za Zhi. 2022 Jul 23;44(7):693-702. doi: 10.3760/cma.j.cn112152-20220412-00244.

Abstract

Drug-induced interstitial lung disease (DILD) is the most common pulmonary adverse events caused by anti-cancer treatment. In recent years, with the development of clinical oncology, a large amount of novel anti-cancer drugs have been approved and widely used in clinical practice, and the incidence of anti-cancer drug related DILD is gradually increasing. DILD lacks specific clinical manifestations or diagnostic criteria. If not treated properly, it may leads to interruption or discontinuation of anti-cancer treatment, or even become life threat in severe cases. Therefore, the Anti-cancer Drug-induced Interstitial Lung Disease Management Group have reached a consensus on the diagnosis and management of anti-cancer DILD after several rounds of discussion. This consensus aims to improve clinicians' awareness of anti-cancer drug related-DILD and proposes an algorithm for the diagnosis and treatment of this disease, and to improve patients' prognosis and quality of life.

摘要

药物性间质性肺疾病(DILD)是抗癌治疗引起的最常见肺部不良事件。近年来,随着临床肿瘤学的发展,大量新型抗癌药物获批并广泛应用于临床实践,抗癌药物相关DILD的发病率逐渐上升。DILD缺乏特异性临床表现或诊断标准。若治疗不当,可能导致抗癌治疗中断或停止,严重时甚至危及生命。因此,抗癌药物性间质性肺疾病管理小组经过几轮讨论,就抗癌DILD的诊断和管理达成了共识。该共识旨在提高临床医生对抗癌药物相关DILD的认识,提出该病的诊断和治疗流程,以改善患者的预后和生活质量。

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