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《肺癌小分子靶向药物合理使用与监测专家共识》

[Expert Consensus on Rational Use and Monitoring of Small Molecule Targeted Drugs for Lung Cancer].

作者信息

Zhao Liyan, Tang Kejing

出版信息

Zhongguo Fei Ai Za Zhi. 2025 Apr 20;28(4):245-255. doi: 10.3779/j.issn.1009-3419.2025.106.10.

Abstract

The application of small molecule targeted drugs for lung cancer has significantly improved the survival of lung cancer patients. However, these drugs have a wide variety of types, fast development and market launch of new drugs, complex adverse reactions, and are mostly used at home, which increases the risk of irrational drug use. At the same time, insufficient monitoring of efficacy and safety is also prone to occur, ultimately affecting treatment outcomes. This consensus focuses on 43 small molecule targeted drugs or combinations for lung cancer, providing standardized recommendations for rational drug use and monitoring of efficacy/adverse reactions in clinical practice. The recommendations are regarding drug selection, dosage adjustment, efficacy monitoring, adverse reaction monitoring, and improvement of patient compliance. This consensus aims to improve the rational use and efficacy/safety monitoring quality of small molecule targeted drugs for lung cancer, ensure the effectiveness and safety of drug treatment, prolong the survival of lung cancer patients and improve their quality of life.
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摘要

小分子靶向药物在肺癌治疗中的应用显著提高了肺癌患者的生存率。然而,这些药物种类繁多,新药研发和上市速度快,不良反应复杂,且多在国内使用,增加了不合理用药的风险。同时,疗效和安全性监测不足也容易发生,最终影响治疗效果。本共识聚焦于43种用于肺癌的小分子靶向药物或联合用药方案,为临床实践中的合理用药及疗效/不良反应监测提供规范建议。这些建议涉及药物选择、剂量调整、疗效监测、不良反应监测以及提高患者依从性等方面。本共识旨在提高肺癌小分子靶向药物的合理使用及疗效/安全性监测质量,确保药物治疗的有效性和安全性,延长肺癌患者生存期并提高其生活质量。

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