Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Clinical Center of Gansu Province for Nephro-urology, Lanzhou University, Lanzhou, China.
Department of Urology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Future Oncol. 2022 Aug;18(26):2933-2942. doi: 10.2217/fon-2022-0223. Epub 2022 Jul 26.
To investigate the prognostic value of preoperative mean platelet volume (MPV), MPV/lymphocyte ratio (MPVLR), MPV/platelet count ratio and plasma fibrinogen in patients with non-muscle invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor (TURBT). A total of 371 patients who underwent TURBT were enrolled. The main end points were disease-free survival (DFS) and overall survival (OS). MPVLR, tumor size, tumor number and pathological grade were independent risk factors for postoperative DFS. Age and pathological grade were independent risk factors for postoperative OS. MPVLR is an independent risk factor for DFS in NMIBC patients and could be used as a parameter to predict postoperative tumor recurrence in patients after TURBT.
探讨经尿道膀胱肿瘤切除术（TURBT）后术前血小板平均体积（MPV）、MPV/淋巴细胞比值（MPVLR）、MPV/血小板计数比值和血浆纤维蛋白原对非肌层浸润性膀胱癌（NMIBC）患者的预后价值。共纳入 371 例接受 TURBT 的患者。主要终点是无病生存率（DFS）和总生存率（OS）。MPVLR、肿瘤大小、肿瘤数量和病理分级是术后 DFS 的独立危险因素。年龄和病理分级是术后 OS 的独立危险因素。MPVLR 是 NMIBC 患者 DFS 的独立危险因素，可作为 TURBT 后患者术后肿瘤复发的预测参数。
