Division of Polymeric Medical Devices, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
J Mater Chem B. 2022 Aug 10;10(31):5913-5924. doi: 10.1039/d2tb00856d.
Novel methods for the delivery of drugs other than the conventional method of oral administration have been a thrust area of research for a few decades. Mucoadhesive delivery of drugs opened up a new domain where rapid and patient-friendly delivery of drugs can be achieved. Delivery of drugs through the mucosal sites such as buccal, nasal, ocular, sublingual, rectal and vaginal facilitates bypassing the first-pass metabolism and the drug reaches the systemic circulation directly. This helps to increase the bioavailability of the drug. The study of the chemical characteristics of polymers with mucoadhesive properties and how the molecules or the pharmaceuticals are transported across the mucosa is very much needed for the advancement of research in this field. And at the same time, it is very pertinent to know about the anatomy and the physiology of the mucosal tissue and its variation in different regions of the body. In this review, we try to present a comprehensive understanding of relevant topics of mucoadhesion giving more emphasis on the mechanism of transport of drugs across mucosa, and different possible functional modifications of polymers to enhance the property of mucoadhesion.
除了传统的口服给药方法外，新型药物输送方法一直是几十年来研究的重点领域。药物的黏膜黏附递送开辟了一个新的领域，可实现快速且患者友好的药物递送。通过黏膜部位（如颊、鼻、眼、舌下、直肠和阴道）输送药物可绕过首过代谢，药物直接进入体循环。这有助于提高药物的生物利用度。研究具有黏膜黏附特性的聚合物的化学特性以及分子或药物如何穿过黏膜的运输方式，对于推进该领域的研究非常必要。同时，了解黏膜组织的解剖结构和生理学及其在身体不同区域的变化也非常重要。在这篇综述中，我们试图全面了解黏膜黏附的相关主题，重点介绍药物穿过黏膜的运输机制，以及聚合物的不同可能的功能修饰，以增强黏膜黏附的特性。
