咖啡因在对茶碱无反应的早产呼吸暂停婴儿中的应用。

Use of caffeine in infants unresponsive to theophylline in apnea of prematurity.

作者信息

Davis J M, Spitzer A R, Stefano J L, Bhutani V, Fox W W

出版信息

Pediatr Pulmonol. 1987 Mar-Apr;3(2):90-3. doi: 10.1002/ppul.1950030210.

DOI:10.1002/ppul.1950030210

Abstract

Eleven premature infants with severe apnea unresponsive to therapeutic theophylline levels were studied to determine if caffeine is an effective treatment in such cases. Apnea was documented and quantitated with thermistor-pneumocardiograms measuring heart rate, thoracic impedance, and nasal air flow. Infants with prolonged central or mixed apnea were then treated with caffeine and restudied. Caffeine reduced the total number of apneic episodes of greater than 10 sec duration by 80% (P less than 0.01) and prolonged episodes of apnea (greater than 20 sec) by 88% (P less than 0.05). These data suggest that caffeine may be effective in the management of apnea of prematurity, particularly the prolonged type, unresponsive to theophylline.

摘要

对11例对治疗性氨茶碱水平无反应的重度呼吸暂停早产儿进行了研究，以确定咖啡因在此类病例中是否为一种有效治疗方法。通过测量心率、胸阻抗和鼻气流的热敏电阻式肺心动图记录并量化呼吸暂停情况。然后对患有持续性中枢性或混合性呼吸暂停的婴儿用咖啡因进行治疗并再次研究。咖啡因使持续时间超过10秒的呼吸暂停发作总数减少了80%（P<0.01），使呼吸暂停持续时间延长（超过20秒）的发作减少了88%（P<0.05）。这些数据表明，咖啡因可能对治疗早产儿呼吸暂停有效，尤其是对氨茶碱无反应的持续性呼吸暂停类型。